Recurrent meningococcal infections in a patient with congenital C5 deficiency

Department of General Internal Medicine, University Hospitals, K. U. Leuven, Belgium.
Acta clinica Belgica (Impact Factor: 0.59). 02/1993; 48(1):42-7.
Source: PubMed


A congenital C5 deficiency was the cause of recurrent meningococcal disease in a 27-year-old man. The lack of serum bactericidal activity accounts for the higher incidence and the different course of Neisseria infections in patients with a deficiency of the late complement components. Early antibiotic treatment and vaccination with a capsular polysaccharide meningococcal vaccine (A,C,Y,W-135) should be considered.

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