Article

Signet-ring stromal tumor of the ovary: a histochemical, immunohistochemical and ultrastructural study.

Departamento de Anatomía Patológica, Hospital La Paz, Madrid, Spain.
Virchows Archiv. A, Pathological anatomy and histopathology 02/1993; 422(4):333-6. pp.333-6
Source: PubMed

ABSTRACT We report a signet-ring stromal tumour found in the ovary of a 50-year-old woman. The solid tumour was composed of spindle and round cells which stained with vimentin and some round cells were vacuolated and had the appearance of signet-ring cells. The vacuoles were negative with periodic acid-Schiff, with and without diastase digestion, with alcian blue, Sudan III, alpha-1-antitrypsin and alpha-fetoprotein stains. Ultrastructurally, they were membrane bound and contained scantly flocculent material. Some neoplastic cells contained intracytoplasmic eosinophilic globules which were positive with alpha-1-antitrypsin. Signet-ring stromal tumour is a benign, morphologically distinctive type of ovarian stromal tumour, which may present problems in differential diagnosis with other stromal and non stromal ovarian neoplasms.

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    Article: Recent advances in the pathology and classification of ovarian sex cord-stromal tumors.
    Lawrence M Roth
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    ABSTRACT: In recent years, our knowledge of ovarian sex cord-stromal tumors has increased, and their classification has evolved. In this review, recent advances in the classification and pathology of ovarian sex cord-stromal tumors are discussed, and the controversy regarding the classification of sex cord tumor with annular tubules is addressed. The current classification is built on those of the past, and future classifications should improve on what is now in place incorporating new knowledge from more sophisticated clinicopathologic studies and advanced molecular techniques. This review emphasizes articles written in the 21st century as well as those that have significantly advanced our knowledge of sex cord-stromal tumors in past decades. The tumors in this group occur over a wide age range and are often unilateral. In difficult cases, immunocytochemistry provides improved diagnostic accuracy. The most useful immunohistochemical marker for their identification is alpha-inhibin, which is positive in most neoplasms in the sex cord-stromal group. The article concludes with a section discussing the pathogenesis of sex cord-stromal tumors.
    International Journal of Gynecological Pathology 08/2006; 25(3):199-215. · 1.45 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

50-year-old woman
 
alcian blue
 
alpha-1-antitrypsin
 
alpha-fetoprotein stains
 
diastase digestion
 
intracytoplasmic eosinophilic globules
 
morphologically distinctive type
 
neoplastic cells
 
non stromal ovarian neoplasms
 
periodic acid-Schiff
 
scantly flocculent material
 
signet-ring cells
 
signet-ring stromal tumour
 
solid tumour
 
spindle