Recurring Phyllodes Tumor in Aberrant Breast Tissue of the Vulva

Department of Pathology, University of Texas Medical Branch, Galveston 77555-0588.
American Journal of Surgical Pathology (Impact Factor: 5.15). 10/1993; 17(9):946-50. DOI: 10.1097/00000478-199309000-00013
Source: PubMed


A 20-year-old nulligravida woman presented with bilateral cystic nodules of the vulva, diagnosed after simple excision as benign phyllodes tumor. Breast tissue, which also displayed fibrocystic changes, was also recognized. Follow-up at 2 months revealed no evidence of disease; however, 8 months after surgery she returned with a new mass in the vulva. This was excised and found to be recurrent phyllodes tumor. Although somewhat more cellular than the first lesions, it also was deemed to be benign based on histological features supported by flow cytometric DNA studies.

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    • "PTs in an ectopic location are rare, and they mostly have been reported in the vulva and axilla.3,5 A review of the literature revealed only four cases in the vulva and two cases in the axilla (Table 1).3,9-12 All cases had normal mammary tissues surrounding the mass. "
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    ABSTRACT: The present lesion was the first reported case of a benign intracystic phyllodes tumor in the inguinal region. We report the case of a 51-year-old female patient who presented with an inguinal mass. A clinical diagnosis of malignant lymphoma was considered in this case. The resected tumor was well-circumscribed and showed numerous papillary nodular protrusions into a central cystic cavity (3.5×2.5 cm). The microscopic findings showed hyperplastic epithelium-lined cysts with leaf-like intraluminal epithelium-lined bland stromal projections. The epithelial cell linings were strongly positive for estrogen and progesterone receptors.
    The Korean Journal of Pathology 12/2013; 47(6):583-6. DOI:10.4132/KoreanJPathol.2013.47.6.583 · 0.17 Impact Factor
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    ABSTRACT: Ectopic breast tissue, found along the mammary line or sometimes outside it, can exhibit pathologic changes similar to those of the eutopic mammary gland. Fibroadenoma phyllodes, an unusual variant of mammary phyllodes tumor with stromal cellularity similar to a conventional fibroadenoma, rarely arises outside of breast. Its histogenesis is unclear; although some cases suggest an origin in cutaneous adnexa, the presence of normal breast tissue surrounding other tumors favors an ectopic mammary origin. Two cases of fibroadenoma phyllodes arising in ectopic vulvar breast tissue are described.
    International Journal of Gynecological Pathology 04/1998; 17(2):171-3. DOI:10.1097/00004347-199804000-00013 · 1.67 Impact Factor
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    ABSTRACT: Phyllodes tumor arising from ectopic breast tissue of the vulva is an extremely rare occurrence. A case is reported in a 34-year-old nulligravida woman, presenting as a nodule on the left labium majus. A simple excision was carried out, and no recurrence has been detected after 18 months of follow-up.
    International Journal of Surgical Pathology 02/2001; 9(1):81-3. DOI:10.1177/106689690100900116 · 0.95 Impact Factor
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