[show abstract][hide abstract] ABSTRACT: Transplantation of tissues and organs is currently the only available treatment for patients with end-stage diseases. However, its feasibility is limited by the chronic shortage of suitable donors, the need for life-long immunosuppression, and by socio-economical and religious concerns. Recently, tissue engineering has garnered interest as a means to generate cell-seeded three-dimensional scaffolds that could replace diseased organs without requiring immunosuppression. Using a regenerative approach, scaffolds made by synthetic, non-immunogenic, biocompatible materials have been developed and successfully clinically implanted. This strategy, based on a viable and ready-to-use bioengineered scaffold, able to promote novel tissue formation, favouring cell adhesion and proliferation, could become a reliable alternative to allotransplatation in the next future. In this paper, tissue engineered synthetic substitutes for tubular organs (such as trachea, esophagus, bile ducts and bowel) are reviewed, including a discussion on their morphological and functional properties.
Journal of Biomedical Materials Research Part A 07/2013; · 2.83 Impact Factor
[show abstract][hide abstract] ABSTRACT: Intestinal resection and malformations in adult and pediatric patients result in devastating consequences. Unfortunately, allogeneic transplantation of intestinal tissue into patients has not been met with the same measure of success as the transplantation of other organs. Attempts to engineer intestinal tissue in vitro include disaggregation of adult rat intestine into subunits called organoids, harvesting native adult stem cells from mouse intestine and spontaneous generation of intestinal tissue from embryoid bodies. Recently, by utilizing principles gained from the study of developmental biology, human pluripotent stem cells have been demonstrated to be capable of directed differentiation into intestinal tissue in vitro. Pluripotent stem cells offer a unique and promising means to generate intestinal tissue for the purposes of modeling intestinal disease, understanding embryonic development and providing a source of material for therapeutic transplantation.
Regenerative Medicine 11/2011; 6(6):743-55. · 3.87 Impact Factor
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