[Protective effect of Neoton during cardiovascular surgery. Hemodynamic and biochemical aspects].
ABSTRACT The authors present the preliminary results of an experimental study where to a group of patients (n = 10) subjected to cardiosurgery, using extracorporeal circulation, to the cardioplegic solution creatine phosphate was added (Neoton of Alfa Schiaparelli Wasserman Co.)--2 g.l-1. The authors investigated haemodynamic and biochemical parameters and compared them on the day of operation with the same parameters assessed in a group of controls operated in the same way but without addition of creatine phosphate to the cardioplegic solution. Apart from insignificant differences in haemodynamic parameters the group of patients given Neoton had a lower malondialdehyde level during the early stage after termination of extracorporeal circulation, spontaneous defibrillation, a lower incidence of dysrhythmias and disorders of the conduction system. It can be assumed that creatine phosphate (Neoton) may be effective in the protection of the myocardium from ischaemia reperfusion damage.