Comparative efficacy of rice-ORS and glucose-ORS in moderately dehydrated Turkish children with diarrhea.
ABSTRACT The efficacy of precooked rice-based (50 g/L) oral rehydration solution (R-ORS) was compared with standard glucose-based ORS (G-ORS) in a randomized controlled trial in 79 children who were moderately dehydrated due to diarrhea. ORS intake rate and weight gain after rehydration were found to be similar in the two treatment groups (p > 0.05). The time necessary for rehydration was significantly lower in the R-ORS-treated group than in the G-ORS-treated group (5.2 +/- 2.2 and 7.5 +/- 3.4 hours, respectively, p < 0.05). Although the mean serum bicarbonate levels were significantly increased in both treatment groups at the end of the treatment, a significant increase in the mean pH value was observed in only the R-ORS treated group (p < 0.05).
- SourceAvailable from: Melinda K Munos[show abstract] [hide abstract]
ABSTRACT: Most diarrhoeal deaths can be prevented through the prevention and treatment of dehydration. Oral rehydration solution (ORS) and recommended home fluids (RHFs) have been recommended since 1970s and 1980s to prevent and treat diarrhoeal dehydration. We sought to estimate the effects of these interventions on diarrhoea mortality in children aged <5 years. We conducted a systematic review to identify studies evaluating the efficacy and effectiveness of ORS and RHFs and abstracted study characteristics and outcome measures into standardized tables. We categorized the evidence by intervention and outcome, conducted meta-analyses for all outcomes with two or more data points and graded the quality of the evidence supporting each outcome. The CHERG Rules for Evidence Review were used to estimate the effectiveness of ORS and RHFs against diarrhoea mortality. We identified 205 papers for abstraction, of which 157 were included in the meta-analyses of ORS outcomes and 12 were included in the meta-analyses of RHF outcomes. We estimated that ORS may prevent 93% of diarrhoea deaths. ORS is effective against diarrhoea mortality in home, community and facility settings; however, there is insufficient evidence to estimate the effectiveness of RHFs against diarrhoea mortality.International Journal of Epidemiology 04/2010; 39 Suppl 1:i75-87. · 6.98 Impact Factor