Article

Treatment of photodamaged skin with trichloroacetic acid and topical tretinoin.

Department of Dermatology, Hospital of the University of Pennsylvania, USA.
Journal of the American Academy of Dermatology (impact factor: 3.99). 05/1996; 34(4):638-44. pp.638-44
Source: PubMed

ABSTRACT Photodamaged skin typically displays lentigines, actinic keratoses, wrinkles, and textural alteration. Chemical peeling has been used to treat these, but few controlled studies have been performed to determine its efficacy.
Our purpose was to compare the efficacy of a medium-depth chemical peel with and without tretinoin before and after treatment.
Sixteen men with actinic damage including actinic keratoses were treated with a 40% trichloroacetic acid(TCA) chemical peel. Half were pretreated for 6 weeks with topical tretinoin; they also used tretinoin after the peel. Photographs were obtained at baseline and at 6 weeks and 6 months after treatment. Changes in specific features were rated by a panel of three examiners.
Some improvement was noted in all patients. More rapid and even frosting was observed in the patients pretreated with tretinoin. Solar lentigines, actinic keratoses, and skin texture were the features of photoaging most affected; wrinkles were least affected. No statistically significant difference was found between patients treated with TCA and tretinoin (before and after peel) and those with TCA alone.
A medium-depth chemical peel with 40% TCA alone produced moderate improvement in some manifestations of actinic damage but had little effect on wrinkles. Treatment with tretinoin before and after TCA did not significantly enhance the efficacy of the peel.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

40% trichloroacetic acid(TCA)
 
6 weeks
 
actinic damage
 
actinic keratoses
 
Chemical peeling
 
controlled studies
 
features
 
frosting
 
medium-depth chemical peel
 
moderate improvement
 
patients
 
patients pretreated
 
skin texture
 
Solar lentigines
 
specific features
 
statistically significant difference
 
textural alteration
 
topical tretinoin
 
tretinoin
 
wrinkles