Lymphomatous polyposis. A neoplasm of either follicular mantle or germinal center cell origin.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.
American Journal of Surgical Pathology (Impact Factor: 4.59). 05/1996; 20(4):442-52.
Source: PubMed

ABSTRACT Lymphomatous polyposis (LP) is generally thought to be an expression of non-Hodgkin's lymphoma (NHL) of follicular mantle cell (MC) origin. We report nine patients with LP from more than 3,500 cases of NHL studied by the Nebraska Lymphoma Study Group. Our patients differed from those reported previously in that LP represented a follicular center cell (FCC) NHL in two of the nine cases, with the remainder consisting of MC NHL. Three patients developed LP during a relapse of previously diagnosed and treated extraintestinal MC NHL (parotid gland, tonsil, and inguinal lymph node, respectively), whereas the other six patients presented with primary LP. In seven of the nine LP cases, a large mass predominated among a myriad of small polyps. The FCC cases were confined to the small intestine, whereas the MC cases were either pan-intestinal or colonic on their localization. Two MC cases studied by Southern blotting exhibited rearrangement of the bcl-1 locus. Bcl-2 rearrangement was not detected in any of the nine cases when studied by either a polymerase chain reaction-based assay (seven cases) or by Southern blotting (two cases). To date, four patients (three MC, one FCC) have experienced recurrent NHL in gastrointestinal sites. With follow-up ranging from 13 to 147 months, the entire group had a median survival of 41 months (primary MC LP:13, 13, 41, and 77 months; primary FCC LP:45 and 147 months; secondary MC LP:17, 41 and 76 months), and only one patient has died. We conclude that LP is a rare manifestation of NHL of either follicular MC or germinal center cell origin.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Résumé Bien que, comparés aux carcinomes, les lymphomes du tractus digestif soient extrêment rares, leur incidence est croissante. Cette croissance peut s'expliquer par une augmentation de l'incidence des perturbation liées à l'immunodéficience, elles-mêmes associées à une augmentation du risque de développer des lymphomes gastro-intestinaux. Les lymphomes gastro-intestinaux sont principalement des lymphomes B de type diffus à grandes cellules et des lymphomes de la zone marginale. Malgré la rareté des autres types de lymphomes tels les lymphomes du manteau, les lymphomes folliculaires ou les lymphomes T associés a une entéropathie, la classification REAL tout comme la classification publiée récemment par l'OMS, considèrent ces lymphomes comme des entités distinctes en se basant sur leur morphologie, l'immunohistochimie, la cytogénétique et leur présentation clinique.
    Acta Endoscopica 06/2003; 33(3):327-345. DOI:10.1007/BF03015747 · 0.16 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Eine 82-jährige Patientin wird aufgrund rektaler Blutabgänge sowie einem tastbaren Unterbauchtumor aufgenommen. Ferner liegt eine Raumforderung in der Axilla vor. Durch die Koloskopie werden multiple Polypen im gesamten Kolon gefunden. Histologisch zeigt sich eindeutig der Befund einer Mantelzell-Lymphoms. Damit kann die Diagnose einer multiplen lymphomatösen Polypose gestellt werden. Unter 6 Zyklen Chemotherapie mit COP konnte bei guter Verträglichkeit eine Vollremission erzielt werden. Nur kurze Zeit später trat jedoch erneut ein Rezidiv der Erkrankung auf, wodurch die Patientin binnen weniger Wochen verstarb.
    Der Internist 09/1998; 39(9). DOI:10.1007/PL00020806 · 0.27 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Lymphomas are solid tumours of the immune system. Hodgkin's lymphoma accounts for about 10% of all lymphomas, and the remaining 90% are referred to as non-Hodgkin lymphoma. Non-Hodgkin lymphomas have a wide range of histological appearances and clinical features at presentation, which can make diagnosis difficult. Lymphomas are not rare, and most physicians, irrespective of their specialty, will probably have come across a patient with lymphoma. Timely diagnosis is important because effective, and often curative, therapies are available for many subtypes. In this Seminar we discuss advances in the understanding of the biology of these malignancies and new, available treatments.
    The Lancet 09/2012; 380(9844):848-57. DOI:10.1016/S0140-6736(12)60605-9 · 39.21 Impact Factor