The occurrence of atopic dermatitis in North Europe: An international questionnaire study

Kristianstad University, Kristianstad, Skåne, Sweden
Journal of the American Academy of Dermatology (Impact Factor: 5). 06/1996; 34(5 Pt 1):760-4. DOI: 10.1016/S0190-9622(96)90009-2
Source: PubMed

ABSTRACT Atopic dermatitis is a common multifactorial disease that seems to be increasing in frequency.
Our purpose was to determine the increased prevalence of atopic dermatitis in North Europe.
Approximately 3000 7-year-old children in Denmark, Germany, and Sweden were enrolled in a cross-sectional questionnaire study that was conducted in the autumn of 1992 with common protocols and standardized procedures.
The response rate was 90%. The frequency of atopic dermatitis was calculated to be 15.6% (95% confidence interval 14.2% to 17%) with some regional differences. Girls more often had flexural eczema and outnumbered boys in a ratio of 1.3:1.0. Boys more often had a personal history of asthma, whereas girls more often had a family history of asthma.
The increasing prevalence of atopic dermatitis has been confirmed. This simple questionnaire model works well, is cost effective, and is sufficiently sensitive and specific to conduct large-scale epidemiologic investigations in school children.

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    • "Atopic dermatitis affects 15 to 20% of preschool children in western countries [1] [2] [3] [4]. The lifetime prevalence of eczema in children aged 1–4 years in Värmland county, Sweden, was assessed in 2000 in the cohort study Dampness in Building and Health to be 22% [5]. "
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    ABSTRACT: Aim. To develop and validate a questionnaire for detecting atopic dermatitis in infants and small children from the age of 2 months. Methods. Parents to 60 children answered a written questionnaire prior to a physical examination and individual semistructured interview. Qualitative and quantitative analyses of validity, sensitivity, specificity, and predictive values of the questionnaire were performed. Results. A total of 27 girls and 33 boys, aged 2 to 71 months, 35 with and 25 without physician-diagnosed eczema, participated. Validation of the questionnaire by comparisons with physicians' diagnoses showed a sensitivity of 0.91 (95% CI 0.77-0.98) and a specificity of 1 (95% CI 0.86-1). Conclusions. Three questions in a parental questionnaire were sufficient for diagnosing eczema in infants and small children.
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    • "Eczematous dermatitis is a chronic inflammatory skin disease, associated with cutaneous hyperreactivity, which usually occurs in individuals with an allergic background (also referred to as atopic dermatitis [AD]). One of its most striking features is the rising incidence during the past two decades, currently approaching 15%–30% of children at some point during childhood (Bieber, 2008; Schultz Larsen et al., 1996). Both genetic and environmental factors contribute to the development of AD (Bieber, 2008; Leung et al., 2007), but the underlying mechanisms by which such factors contribute to the pathogenesis of dermatitis are poorly defined. "
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    Immunity 10/2011; 35(4):562-71. DOI:10.1016/j.immuni.2011.07.013 · 19.75 Impact Factor
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    • "Environmental factors and psychosocial stress have been implicated in its exacerbation [1] [3] [4]. It has been estimated that patients with AD account for 30% of dermatology consultations in primary care and up to 20% of all referrals to dermatologists [1]. "
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