Article

Long-term sequelae of hearing impairment in congenital hypothyroidism.

Department of Psychology and Communication Disorders, Hospital for Sick Children, Toronto, Ontario, Canada.
Journal of Pediatrics (impact factor: 4.11). 07/1996; 128(6):776-83. pp.776-83
Source: PubMed

ABSTRACT Hearing loss and its functional consequences were evaluated retrospectively in children with congenital hypothyroidism. From a cohort of 101 children followed longitudinally to evaluate newborn screening, 75 with previous hearing tests were studied. Fifteen (20%) were found to have hearing problems. Of these, nine had unilateral or sensorineural loss mostly at high frequencies, five had a conductive loss, and one had both problems. Hearing impaired children differed from children with normal hearing in age of treatment onset (22 vs 14 days) but not disease severity or duration. A comparison of language and auditory processing skills at ages 3, 5, and 7 years revealed that early speech was delayed in hearing impaired children, whereas deficits persisted in later receptive language and auditory discrimination skills. Comparing hearing impaired children and children with normal hearing with matched control subjects at grade 3 showed that hearing impaired children were poorer readers because of less adequate phonologic processing skills.

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    Article: Neurocognitive aspects of hypothyroidism.
    A T Dugbartey
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    ABSTRACT: Hypothyroidism is associated with significant neurocognitive deficits that develop across the life span. This article discusses the patterns of cognitive deficits associated with congenital and adult-onset hypothyroidism. A review of the extant literature shows that the successful treatment of clinically evident thyroid gland hypofunction, resulting in a return to euthyroidism in both infants and adults, may be associated with only partial and typically inconsistent patterns of recovery of overall neurocognitive function. In addition to demonstrating different patterns of cognitive impairments, patients with congenital and acquired adult-onset hypothyroidism have variable responses to thyroid replacement therapy, which increases the risk of higher neurocognitive morbidity associated with congenital hypothyroidism. An evaluation of the commonly held view that hypothyroid dementia is an imminently reversible condition is only partially supported by the medical literature, which is fraught with methodological and conceptual shortcomings. I offer some recommendations for addressing the cognitive and behavioral management concerns of individuals with clinical hypothyroidism.
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    Conference Proceeding: Temporal and frequency analysis of click-evoked otoacoustic emissions recorded from untreated congenital hypothyroid newborns
    M. Ravazzani, P. Ravazzani, S. Medaglini, G. Weber, G. Tognola, C. Fornara, C. Bianchi, G. Comi, G. Chiumello, F. Grandori
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    ABSTRACT: Thyroid hormone plays an important role in hearing development The exact incidence of hearing impairment in untreated congenital hypothyroid newborns (CH) is unknown. This paper presents the results of the measuring of the transient-evoked otoacoustic emissions (TEOAE) on a population of 29 newborns positive to the screening test for hypothyroidism. TEOAE were recorded in all newborns in 1 month after birth and before starting the L-thyroxin treatment. We performed both temporal and time-frequency analysis of the responses by means of wavelet transform 68 newborns who had no risk factor for hearing loss served as control. The comparison of the characteristics of temporal and frequency content of the responses of the two groups showed no statistically significant difference (p=0.01).
    Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE; 02/2001
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Keywords

adequate phonologic processing skills
 
ages 3
 
auditory discrimination skills
 
auditory processing skills
 
children
 
cohort
 
Comparing hearing
 
control subjects
 
deficits
 
functional consequences
 
grade 3
 
Hearing loss
 
hearing problems
 
newborn screening
 
normal hearing
 
previous hearing tests
 
problems
 
receptive language
 
sensorineural loss
 
treatment onset
 

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