Article

Seasonal variations in the onset of ulcerative colitis

Uppsala University Hospital, Uppsala, Uppsala, Sweden
Gut (Impact Factor: 13.32). 04/1996; 38(3):376-8. DOI: 10.1136/gut.38.3.376
Source: PubMed

ABSTRACT Several retrospective studies have reported seasonal variations in the relapse of ulcerative colitis, and two studies have found seasonality in the onset of ulcerative colitis, with a peak from August to January. This study was designed to investigate possible seasonal variations of onset of ulcerative colitis (UC) and Crohn's disease (CD). Patients with symptoms of one year or less were recruited from a prospective study of the incidence of inflammatory bowel disease, and the onset of symptoms was recorded month by month for four consecutive years. A total of 420 patients with UC and 142 patients with CD were included. There was monthly seasonality (p = 0.028) in symptomatic onset in December and January for UC but not for CD. It was found that environmental agents with known seasonality can be of importance for the seasonal variations of disease onset in UC.

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Available from: Morten H Vatn, May 14, 2014
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    • "As previously noted by our group, the endoscopic diagnosis date should not be used to assess the occurrence of seasonal variation in a study that aimed to investigate the etiopathogenesis of the disease (Basaranoglu et al., 2006; Basaranoglu, 2006). Although few studies designed according to the above-mentioned criteria reported a seasonal variation in IBD, prior limited results are conflicting and the presence of a seasonal pattern in patients with IBD remains unestablished (Moum et al., 1996; Aratari et al., 2006). "
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    ABSTRACT: Environmental factors are believed to trigger the onset of Inflammatory bowel disease (IBD). We aimed to evaluate the seasonal variation in the onset of symptoms in patients with IBD and health care seeking behaviour. 282 patients were chosen from the charts. Demographic features, the month and the age at the onset of presenting symptoms and delayed diagnosis term for each patient were analyzed. Cumulative monthly averages analysed by Kruskal Wallis test and Roger's test. Of the 282 patients with IBD, 181 were male (64%). Mean age was 40.1±14.7 years (median: 38, range: 14 to 79 years). The seasonal pattern showed peak in March with 57% and the lowest point in November with 36% (p <0.05). The delayed diagnosis term was 3.0 ± 2.3 months in males vs 3.2 ± 3.2 months in females (p >0.05). The seasonal pattern was not influenced by both genders and by age groups in patients with IBD or UC or CD (p >0.05). We investigated the etiologic environment of IBD and found an interaction between the etiopathogenesis of IBD and environmental risk factors. There was a delay in IBD, but no difference on the health care seeking behaviour between males and females.
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    • "However, other studies have reported no seasonal variations in the onset of symptoms in UC [16]. The only prospective study addressing seasonality in the onset of symptoms was performed in Norway [17]: symptomatic onset of UC occurred more frequently in December and January but no seasonality was observed in CD. "
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