Article

Immunosuppressive potential and pathogenicity of an avian adenovirus isolate involved in hydropericardium syndrome in broilers.

Animal Health Laboratories, National Agricultural Research Centre, Islamabad, Pakistan.
Avian Diseases (impact factor: 1.46). 39(4):723-8. pp.723-8
Source: PubMed

ABSTRACT The role of avian adenovirus isolate PARC-1 as an immunosuppressive agent was investigated using a Newcastle disease virus (NDV) vaccine immune response procedure. The immunosuppressive effect on the humoral immune response was investigated up to 21 days after inoculation with adenovirus. Infected chickens showed a serologic response to NDV that was reduced compared with that of the controls. To further investigate the effect of the virus on major lymphoid organs, the pattern of virus dissemination in various organs was studied at various time intervals after inoculation. Spleen, thymus, bursa of Fabricius, and cecal tonsils of broilers were examined using a dot-immunobinding assay. The virus was found to have a predilection for lymphoid organs, and virus from lymphoid organs was capable of producing disease when inoculated into healthy chickens. The relationship of virus predilection to its immunosuppressive effect also was studied.

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Keywords

adenovirus
 
avian adenovirus
 
broilers
 
cecal tonsils
 
dot-immunobinding assay
 
healthy chickens
 
humoral immune response
 
immunosuppressive agent
 
immunosuppressive effect
 
Infected chickens
 
inoculation
 
lymphoid organs
 
major lymphoid organs
 
Newcastle disease virus
 
serologic response
 
thymus
 
various organs
 
various time intervals
 

K Naeem