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Lepore L, Martelossi S, Pennesi M, et al. Prevalence of celiac disease in patients with juvenile chronic arthritis

University of Florence, Florens, Tuscany, Italy
Journal of Pediatrics (Impact Factor: 3.74). 09/1996; 129(2):311-3. DOI: 10.1016/S0022-3476(96)70262-7
Source: PubMed

ABSTRACT We estimated the prevalence of celiac disease in children with juvenile chronic arthritis (JCA), using antiendomysium antibodies as the screening test to select patients for intestinal biopsy. We studied 119 children with JCA and found four patients with antiendomysium antibodies. In three of these patients (2.5%), intestinal biopsy revealed villous atrophy; in the fourth the intestinal mucosa was normal. We conclude that the prevalence of celiac disease is increased in patients with JCA.

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    • "The association between coeliac disease (CD) and a wide spectrum of autoimmune diseases (AID) such as type 1 diabetes mellitus [1] [2], autoimmune thyroid disease [3], juvenile idiopathic arthritis [4] or autoimmune liver disease [5] has been well documented in the medical literature before. The appearance of CD -specific antibodies has also been described in patients with other AID, like systemic lupus erythematosus (SLE), with much lower prevalence and controversial clinical relevance, since not all of them were diagnosed as coeliac following intestinal biopsy [6] [7] "
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    ABSTRACT: The prevalence of coeliac disease (CD) in systemic lupus erythematosus (SLE) is unclear since evidence of this co -association is scarce. Furthermore, CD -specific antibodies have been described in patients with SLE without biopsy -confirmed CD. Here we describe the diagnostic challenges of CD in a patient suffering from SLE and secondary antiphospholipid syndrome, with transient positive serum levels of CD -specific antibodies, with an increased genetic risk for CD, demonstrated by HLA-DQ2 positivity. Guidance is still needed for the CD diagnosis in some atypical conditions
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    • "All symptoms of coeliac disease are eliminated following removal of gluten-containing cereals (wheat, rye, barley and oats). RA has frequently been demonstrated to occur concurrently with coeliac disease (Collins & Maki, 1994; Lepore et al. 1996). Multiple studies of arthritic patients have demonstrated elevated antibody levels for gliadin (O'Farrelly et al. 1988; Lepore et al. 1993), and gluten-free diets have been shown to be effective in reducing arthritic symptoms in coeliac patients (Bourne et al. 1985; Charkravarty & Scott, 1992; Lepore et al. 1993). "
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    ABSTRACT: Despite the almost universal clinical observation that inflammation of the gut is frequently associated with inflammation of the joints and vice versa, the nature of this relationship remains elusive. In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. In genetically susceptible individuals, this antigenic stimulation may ultimately result in the expression of overt rheumatoid arthritis (RA) via molecular mimicry, a process whereby foreign peptides, similar in structure to endogenous peptides, may cause antibodies or T-lymphocytes to cross-react with both foreign and endogenous peptides and thereby break immunological tolerance. By eliminating dietary elements, particularly lectins, which adversely influence both enterocyte and lymphocyte structure and function, it is proposed that the peripheral antigenic stimulus (both pathogenic and dietary) will be reduced and thereby result in a diminution of disease symptoms in certain patients with RA.
    British Journal Of Nutrition 04/2000; 83(3):207-17. DOI:10.1017/S0007114500000271 · 3.34 Impact Factor
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