Article

Rollinecins A and B: two new bioactive annonaceous acetogenins from Rollinia mucosa.

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
Journal of Natural Products (impact factor: 3.13). 06/1996; 59(5):548-51. DOI:10.1021/np960128n pp.548-51
Source: PubMed

ABSTRACT Two new mono-THF ring acetogenins, rollinecins A (1) and B (2), were isolated from the partitioned ethanolic extracts of the leaves of Rollinia mucosa (Annonaceae) by activity-directed fractionation. 1 and 2 are epimeric at the C-14 carbinol stereocenter. Their absolute stereochemical structures were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed equivalent and selective in vitro activities against several human solid tumor cell lines.

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Keywords

human solid tumor cell lines
 
new mono-THF ring acetogenins
 
respective per-Mosher ester derivatives
 
Rollinia mucosa
 
vitro activities
 

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