Primary malignant lymphoma of the uterine cervix: Report of a case with cytologic and immunohistochemical diagnosis

Pathology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.
Cytopathology (Impact Factor: 1.48). 07/1996; 7(3):204-10. DOI: 10.1046/j.1365-2303.1996.39182391.x
Source: PubMed


A non-Hodgkin's lymphoma initially diagnosed on the cervical smear in a 69-year-old asymptomatic female is described. The cytologic findings strongly suggested the presence of a malignant lymphoid neoplasm: neoplastic cells were round, loosely arranged, with scanty cytoplasm and cleaved nuclei. Histological evaluation of the cervical biopsy revealed a diffuse lymphoid proliferation of mononucleated cleaved cells beneath an ulcerated epithelium. Immunohistochemically, the tumour cells were positive for B cell markers. Reports on cytologic features of primary malignant lymphoma of the cervix are not frequent in the literature. We emphasize the importance of their recognition and the differential diagnosis of cervical lymphoma from other neoplastic and non-neoplastic lesions.

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  • Current Diagnostic Pathology 01/1997; 4(3):145-169.

  • Current Diagnostic Pathology 09/1997; 4(3):145-169. DOI:10.1016/S0968-6053(05)80004-3
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    ABSTRACT: BACKGROUND There are few reports on the cytologic features of small cell carcinoma (SMCC) of the uterine cervix.METHODS The clinical records, histopathology, and available cervical smears from all cases of SMCC of the uterine cervix in the files of the British Columbia Cancer Agency between 1985 and 1997 were reviewed.RESULTSCervical smears were available from 11 of 13 identified cases. Six cases had a pretreatment smear containing numerous definitely malignant cells. In the seven cases with reported negative smears, review of the most recent smears detected a missed high grade squamous intraepithelial lesion in one case and rare suspicious epithelial cells in a second case. These two cases were considered to be false-negative smears on review. None of the six malignant smears were diagnosed as SMCC on cervical smears. These smears were reported as malignant epithelial cells, not otherwise specified in three cases and misclassified as adenocarcinoma in three cases. These malignant smears contained cells dispersed as single cells or arranged as loosely cohesive sheets or gland-like aggregates. Tumor cells, ranging from small to large, had extremely pleomorphic, angulated nuclei that were hyperchromatic and showed nuclear molding and smearing. Mitotic figures were common and karyorrhectic debris was identified in all cases.CONCLUSIONS The routine cervical smear is a relatively insensitive and nonspecific method of detecting SMCC. The specific diagnosis of SMCC on cervical smears is difficult. SMCC can mimic inflammatory cells, follicular cervicitis, endometrial cells, endocervical adenocarcinoma, squamous cell carcinoma of small cell type, non-Hodgkin's lymphoma, and other unusual malignant neoplasms. The suspicion of SMCC on a cervical smear should prompt an urgent biopsy to establish the diagnosis and initiate prompt treatment. Cancer (Cancer Cytopathol) 1998;84:281-288. © 1998 American Cancer Society.
    Cancer 10/1998; 84(5):281 - 288. DOI:10.1002/(SICI)1097-0142(19981025)84:5<281::AID-CNCR3>3.0.CO;2-W · 4.89 Impact Factor
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