Congenital heterotopic gastrointestinal cyst of the oral cavity in a neonate: case report and review of literature.
ABSTRACT Heterotopic gastrointestinal cysts of the oral cavity are rare benign lesions which may mimic both benign and malignant neoplasms. These cysts are usually discovered during infancy, but may not appear until well into adulthood. This lesion involves the tongue and floor of the mouth in 97% of cases and has a male predilection. The cyst may range in size from less than 1 cm to 9 cm, with most lesions being 1-3 cm in size. About 30% of affected individuals have symptoms related to difficulties with feeding, swallowing and respiration. The epithelial lining is quite variable, but all cysts have an enteric lining. The histogenesis is related to entrapment of undifferentiated, noncommitted endoderm within the oral cavity during the 3rd-4th week of fetal life. The purpose of this paper is to report a congenital heterotopic gastrointestinal cyst of the oral cavity presenting in a neonate. The clinical and histopathologic features of this cyst are reviewed, as well as the histogenesis of this lesion.
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ABSTRACT: Gastrointestinal cyst found within the oral cavity has been reported as a rare occurrence with less than 40 cases. The tongue is the preferred site with almost 60% of cysts occurring within oral cavity. The cyst usually shows an asymptomatic swelling in the floor of the mouth, about 30% of affected individuals have symptoms related to difficulties with feeding, swallowing and respiration. The histopathologic features of the cyst vary with respect to the type of epithelium lining; gastric, squamous, intestinal and respiratory epithelium. The pathogenesis is not known, but it may be related to entrapment of undifferentiated endoderm within oral cavity during early fetal development. In this article, we report a case of a gastrointestinal cyst of the tongue in a 16-month-old girl.01/2011; 33(1).
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ABSTRACT: Oral dysontogenic cysts result from defective embryonic development. Among them teratoid cysts are the most unusual presentation and may be lined by gastric, intestinal, respiratory, squamous, ciliated epithelium or even pancreatic structures. Teratoid cysts containing respiratory and gastrointestinal epithelium have typically been called choristomas. This article describes a 15-year-old boy presenting a choristoma involving both the floor of the mouth and the anterior tongue and characterized by the presence of squamous epithelium with skin adnexa, gastric and respiratory epithelium.Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 07/2013; DOI:10.1016/j.joms.2013.04.020 · 1.58 Impact Factor
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ABSTRACT: Adenosquamous carcinomas of the head and neck (ADSCs) are rare locally aggressive malignancies characterized by the presence of two distinctive components, a squamous cell carcinoma and an adenocarcinoma. The immunophenotype of the glandular component of ADSCs has only been rarely studied but has been reported as being positive for keratin 7 (CK7) and carcinoembryonic antigen (CEA) and negative for keratin 20 (CK20). Herein, we report a case of an ADSCs of the hypopharynx composed of a superficial squamous cell carcinoma and an adenocarcinoma with an intestinal phenotype. The patient was a 62 year-old male with a T2 N0 M0 squamous cell carcinoma (SCC) of uvula and palate and a T1 N0 M0 of right hypopharynx. The ADSCs of the hypopharynx was composed of a minimally invasive SCC and an adenocarcinoma with tubulo-glandular and cribriform architecture. The neoplastic glands were positive for CK7, CK20, CDX2, CEA and Villin. The patient underwent radiotherapy to both tumors and remains well with no evidence of recurrent disease 19 months after treatment. To the best of our knowledge, this is the first report of an ADSCs of the head and neck with an intestinal phenotype in its glandular component.Head and Neck Pathology 12/2013; DOI:10.1007/s12105-013-0515-3