Article

High-dose BCNU and autologous progenitor cell transplantation given with intra-arterial cisplatinum and simultaneous radiotherapy in the treatment of high-grade gliomas: benefit for selected patients.

Department of Oncology, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Bone Marrow Transplantation (impact factor: 3.75). 08/1996; 18(1):143-9. pp.143-9
Source: PubMed

ABSTRACT A phase II study of postoperative high-dose carmustine (HDBCNU), intracarotid cisplatin (CDDP), and radical radiotherapy in patients with high-grade glioma was performed. Patients underwent 4-6 consecutive days of blood hematopoietic progenitor cell (HPC) apheresis without prior mobilization. Chemotherapy included intracarotid CDDP, 60 mg/m2, and BCNU, 900 mg/m2. HPC were infused 48 h after HDBCNU. Whole brain irradiation, up to 50 Gy, was started on the 8th day after HPC infusion. With a median follow-up time of 44 months, median overall survival was 15.5 months. Eight patients (23.5%) are alive free of disease 2-6 years after treatment (seven out of 25 patients with glioblastoma multiforme and one out of nine patients with anaplastic astrocytoma). Survival was influenced by young age, good performance and complete surgical resection. Two patients (5.8%) died of therapy-related complications. Acute hematological toxicity of HDBCNU was moderate, with a full recovery on day 26. No acute pulmonary or hepatic toxicity was found. Late severe neurological toxicity was observed in one third of patients surviving beyond 2 years. We conclude that HDBCNU, 900 mg/m2, intracarotid CDDP and radical radiotherapy appear to benefit some patients with high-grade gliomas, and phase III studies should preferentially select young patients with resectable tumors.

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    Article: A low-field intraoperative MRI system for glioma surgery: is it worthwhile?
    Dennis S Oh, Peter M Black
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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

25 patients
 
4-6 consecutive days
 
44 months
 
Acute hematological toxicity
 
blood hematopoietic progenitor cell
 
complete surgical resection
 
glioblastoma multiforme
 
HDBCNU
 
HPC infusion
 
intracarotid CDDP
 
median follow-up time
 
Patients
 
phase II study
 
phase III studies
 
postoperative high-dose carmustine
 
radical radiotherapy
 
resectable tumors
 
Whole brain irradiation
 
young age
 
young patients