Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 22: 707

Erasme University Hospital, Brussels, Belgium.
Intensive Care Medicine (Impact Factor: 7.21). 08/1996; 22(7):707-10. DOI: 10.1007/BF01709751
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Available from: Rui Moreno, May 09, 2014
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    • "The expected mortality rate (EMR) is calculated from the SAPS3. The Sequential Organ Failure Assessment (SOFA) score was developed to better describe the progression of organ failure with a simple scoring system [14] and is calculated daily. The SOFA is used to estimate the degree of organ dysfunction. "
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    ABSTRACT: The purposes of the study are to compare point-of-care (POC) hemostatic devices in critically ill patients with routine laboratory tests and intensive care unit (ICU) outcome scoring assessments and to describe the time course of these variables in relation to mortality rate. Patients admitted to the ICU with a prognosis of more than 3 days of stay were included. The POC devices, Multiplate platelet aggregometry, rotational thromboelastometry, and ReoRox viscoelastic tests, were used. All variables were compared between survivors and nonsurvivors. Point-of-care results were compared to prothrombin time, activated partial thromboplastin time, platelet count, fibrinogen concentration, and Sequential Organ Failure Assessment score and Simplified Acute Physiology Score 3. Blood was sampled on days 0 to 1, 2 to 3, and 4 to 10 from 114 patients with mixed diagnoses during 237 sampling events. Nonsurvivors showed POC and laboratory signs of hypocoagulation and decreased fibrinolysis over time compared to survivors. ReoRox detected differences between survivors and nonsurvivors better than ROTEM and Multiplate. All POC and routine laboratory tests showed a hypocoagulative response in nonsurvivors compared to survivors. ReoRox was better than ROTEM and Multiplate at detecting differences between surviving and nonsurviving ICU patients. However, Simplified Acute Physiology Score 3 showed the best association to mortality outcome. Copyright © 2015. Published by Elsevier Inc.
    Journal of critical care 06/2015; DOI:10.1016/j.jcrc.2015.06.014 · 2.00 Impact Factor
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    • "c Mean ± standard deviation. d SOFA score, the Sequential Organ Failure Assessment score, a scoring system to determine the extent of a person's organ function or rate of failure [12]. e P/F ratio, ratio of PaO 2 /FiO 2 , an index of arterial oxygenation efficiency that corresponds to ratio of partial pressure of arterial O 2 to the fraction of inspired O 2 . "
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    ABSTRACT: Sepsis is a major cause of death worldwide. It triggers systemic inflammation, the role of which remains unclear. In the current study, we investigated the induction of microRNA (miRNA) during sepsis and their role in the regulation of inflammation. Patients, on days 1 and 5 following sepsis diagnosis, had reduced T cells but elevated monocytes. Plasma levels of IL-6, IL-8, IL-10 and MCP-1 dramatically increased in sepsis patients on day 1. T cells from sepsis patients differentiated primarily into Th2 cells, whereas regulatory T cells decreased. Analysis of 1163 miRNAs from PBMCs revealed that miR-182, miR-143, miR-145, miR-146a, miR-150, and miR-155 were dysregulated in sepsis patients. miR-146a downregulation correlated with increased IL-6 expression and monocyte proliferation. Bioinformatics analysis uncovered the immunological associations of dysregulated miRNAs with clinical disease. The current study demonstrates that miRNA dysregulation correlates with clinical manifestations and inflammation, and therefore remains a potential therapeutic target against sepsis.
    Cytokine 01/2015; 71(1):89–100. DOI:10.1016/j.cyto.2014.09.003 · 2.66 Impact Factor
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    • "Demographics, admission diagnostics (classified as sepsis, multiple trauma, burn injury, post-operative state, lymphoma/leukemia/multiple myeloma, and other), and APACHE II [6] score were obtained at the ICU admission. The SOFA [7] "
    Journal of Hepatology 01/2015; 62(5). DOI:10.1016/j.jhep.2015.01.009 · 11.34 Impact Factor
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