Article

[Effect of etoposide on a human pancreatic cancer cell line exposed to high dose X-ray irradiation].

Dept. of Surgery 1, Kyushu University, Faculty of Medicine.
Gan to kagaku ryoho. Cancer & chemotherapy 11/1996; 23(12):1673-5. pp.1673-5
Source: PubMed

ABSTRACT Effects of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high-dose X-ray irradiation were examined. Both high dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicate that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by prior treatment with etoposide.

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Keywords

24-hr prior treatment
 
30 gray irradiation
 
accumulation
 
apoptosis
 
dose X-ray irradiation
 
high-dose X-ray irradiation
 
human pancreatic cancer cell line
 
human pancreatic cancer cell line induced
 
larger percentage
 
pancreatic cancer cells
 
S phase
 
simultaneous treatment