First data on background levels of non-ortho and mono-ortho PCBs in blood of residents from Southern Germany

Ministry of Labour, Health and Social Welfare Baden-Wurttemberg, Stuttgart, Germany.
Chemosphere (Impact Factor: 3.5). 03/1996; 32(3):567-74. DOI: 10.1016/0045-6535(95)00351-7
Source: PubMed

ABSTRACT Blood-fat concentrations of polychlorinated biphenyls (PCB) congeners: no. 105, 118, 156 (mono-ortho-substituted) and no. 77, 126, 169 (non-ortho-substituted) and PCB congeners no. 28, 52, 101, 138, 153 and 180 were measured. The investigations were carried out in pooled samples from children and in individual samples from adults. Additionally polychloro-p-dibenzodioxins and -furans (PCDD/PCDF) were investigated.

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    • "Comparison of PCB congener profiles in blood (Wuthe et al., 1996), human milk (WHO, 1996), and follicular fluid (this work). For each matrix, congener concentrations have been normalized with respect to the most abundant congener (PCB 153). "
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    ABSTRACT: Based on observations in animals, there is an increasing evidence that a number of persistent organochlorine pollutants can alter the endocrine homeostasis, this resulting in toxic effects in particular in the developing organism. However, the role of these chemicals in determining endocrine-related diseases in humans, and possibly a decrease of fertility, is still controversial. Exposure data concerning the human reproductive system are essential for risk assessment. Based on this, the occurrence in follicular fluid of polychlorobiphenyls (PCBs), 2,3,7,8-chlorosubstituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT) and its metabolites, and hexachlorobenzene (HCB) was investigated. With respect to PCBs, the sum of the three most abundant congeners (PCBs 138, 153 and 180) was 1230 ng/g, lipid basis (0.37 ng/g, wet weight). Congener distribution profile overlapped what is usually observed in other human tissues, as blood and milk. PCDDs, PCDFs, p,p'-DDT and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDD) were below their determination limits. 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE) and HCB were detected in concentrations respectively in the order of 700 and 70 ng/g, lipid basis (approximately 0.2 and approximately 0.02 ng/g, wet weight).
    Chemosphere 04/2004; 54(10):1445-9. DOI:10.1016/j.chemosphere.2003.10.040 · 3.50 Impact Factor
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    ABSTRACT: Due to their physico-chemical characteristics, polychlorinated biphenyls (PCBs) are highly persistent in the environment and therefore easily measured in the biological matrices of more and more large groups of general population. For these reasons it would be useful to determine suitable Reference Values (RVs) for these xenobiotics. In this paper, a metanalysis to the published data on PCBs values in human blood is presented. This investigation was carried out in order to reach adequate information on their RVs and to focus some specific topics to be taken into account when producing directly RVs for PCBs. The PCBs RVs resulted between 1.2 e 8.28 microg/L for males and between 2.69 e 5.17 microg/L for females the general range varied from 0.9 to 56 microg/L. The main criticisms in the assessment of RVs for PCBs resulted: the number of examined subjects; the inclusion and stratification criteria; the analytical method adopted and their quality assurance; the type and number of congeners to be determined and their specific quantification; the calculation of blood PCBs concentration (weight/volume or weight/lipids); the statistical analysis and in particular the treatment of not detectable data.
    Giornale italiano di medicina del lavoro ed ergonomia 26(1):3-11.
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    ABSTRACT: Fragestellung. Geographische Unterschiede in der Belastung mit polychlorierten Biphenylen (PCB) und Hexachlorbenzol (HCB) liegen angesichts ihrer Verbreitung als Industrieemissionen und Fungizide nahe und konnten tierexperimentell sowie im globalen Rahmen auch beim Menschen nachgewiesen werden. Ziel der vorliegenden Untersuchung war es, an einem Kollektiv gesunder Neugeborener etwaige regionale Unterschiede in der pränatalen Belastung mit PCB und HCB zwischen einem ländlichen Kleinstadtbereich und einem Großstadtballungszentrum in Deutschland zu untersuchen. Patienten und Methode. Es wurden jeweils 100 reife, gesunde Neugeborene erfasst, die im Untersuchungszeitraum (1998) in Fulda bzw. Düsseldorf geboren wurden. Allen Kindern wurde innerhalb der ersten Lebensstunden, in jedem Fall vor der ersten oralen Nahrungsaufnahme, eine Blutprobe entnommen. Im Serum wurden sodann die 6 PCB-Kongenere 28, 52, 101, 138, 153 und 180 sowie HCB kapillar-gaschromatographisch mit ECD-Detektion bestimmt. Die Untersuchungsgruppen wurden mit dem Wilcoxon-Test für unabhängige Stichproben auf Mittelwertunterschiede untersucht. Ergebnisse. Bezüglich Gestationsalter, Geburtsgewicht und Alter der Mütter bestand kein statistisch signifikanter Unterschied zwischen den beiden Untersuchungsgruppen aus Fulda und Düsseldorf. Das Gleiche galt für die 3 nachweisbaren, höher chlorierten PCB-Kongenere 138, 153 und 180. Dagegen wiesen die Düsseldorfer Neugeborenen signifikant höhere HCB-Konzentrationen auf (Median: 0,26 vs. 0,16 μg/l) als die Kinder aus Fulda. Schlussfolgerungen. Es gibt in den von uns untersuchten Regionen Deutschlands derzeit keine nachweisbaren Unterschiede in der pränatalen PCB-Belastung, die auf einen Unterschied im Wohnumfeld (Stadt vs. Land) zurückgeführt werden könnten. Dafür zeigen Neugeborene aus einem Großstadtballungszentrum signifikant höhere HCB-Belastungen. Mögliche Ursachen hierfür werden aufgezeigt. Insgesamt ist jedoch zu erwarten, dass sich – parallel zur allgemeinen Abnahme der Schadstoffbelastung in Deutschland – auch die Unterschiede in der HCB-Belastung in den nächsten Jahren ausgleichen werden. Question. In face of the global distribution of polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB), regional differences in the human burden with these substances are anticipated and could be demonstrated in animal research as well as in humans in a global context. It was the aim of the present study to investigate whether there are any regional differences in the prenatal burden with PCBs and HCB in a rural vs. metropolitan area in Germany. Patients and methods. Each 100 full-term healthy newborns were recruited who were born in Fulda and Düsseldorf, respectively, in 1998. A blood sample was taken from each newborn within the first hours of life, in every case before the first oral feeding. Six PCB congeners (28, 52, 101, 138, 153, and 180) as well as HCB were determined in serum with capillary gaschromatography with ECD-detection. The results of both study groups were tested on mean differences with Wilcoxon's test for independent samples. Results. There were no statistically significant differences between both study groups with regard to gestational age, birth weight and maternal age. The same applied to the three detectable, higher-chlorinated PCB congeners 138, 153, and 180. Only HCB concentration was significantly higher in the newborns from Düsseldorf as compared with those from Fulda (0.26 vs. 0.16 μg/l). Conclusions. We could not demonstrate evidence for obvious differences in the prenatal burden with PCBs in two defined regions of Germany today. On the other hand, neonates born in a metropolitan area have significantly higher HCB concentrations than newborns from a rural area. Possible explanations for this finding are discussed. It is suggested that these differences will be evened out in the next years according to the general decline in the neonatal burden with these organochlorine compounds in Germany.
    Monatsschrift Kinderheilkunde 149(3):283-287. DOI:10.1007/s001120050762 · 0.28 Impact Factor
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