First data on background levels of non-ortho and mono-ortho PCBS in blood of residents from Southern Germany

Ministry of Labour, Health and Social Welfare Baden-Wurttemberg, Stuttgart, Germany.
Chemosphere (Impact Factor: 3.34). 03/1996; 32(3):567-74. DOI: 10.1016/0045-6535(95)00351-7
Source: PubMed


Blood-fat concentrations of polychlorinated biphenyls (PCB) congeners: no. 105, 118, 156 (mono-ortho-substituted) and no. 77, 126, 169 (non-ortho-substituted) and PCB congeners no. 28, 52, 101, 138, 153 and 180 were measured. The investigations were carried out in pooled samples from children and in individual samples from adults. Additionally polychloro-p-dibenzodioxins and -furans (PCDD/PCDF) were investigated.

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    • "In comparison, the mean TEQ in the Chapevsk boys was 19.3 pg TEQ/g lipid. With the exception of children described by Wuthe et al. [27], subjects in the other studies in Figure 2 were significantly older than the Chapaevsk boys. Despite age differences, the mean TEQ in Chapaevsk boys was comparable to or even higher than the mean TEQ in older populations from other countries. "
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    ABSTRACT: Toxicological studies and limited human studies have demonstrated associations between exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) and adverse developmental and reproductive health effects. Given that children may be particularly susceptible to reproductive and developmental effects of organochlorines, and the paucity of information available regarding childhood exposures to dioxins in particular, we undertook a pilot study to describe the distribution of, and identify potential predictors of exposure to, dioxin-like compounds and dioxins among adolescent boys in Chapaevsk, Russia. The pilot study was also designed to guide the development of a large prospective cohort study on the relationship of exposure to PCDDs, PCDFs, and PCBs with growth and pubertal development in peri-pubertal Chapaevsk boys. 221 boys age 14 to 17 participated in the pilot study. Each of the boys, with his mother, was asked to complete a nurse-administered detailed questionnaire on medical history, diet, and lifestyle. The diet questions were used to measure the current and lifetime consumption of locally grown or raised foods. Blood samples from 30 of these boys were sent to the Centers for Disease Control and Prevention (CDC) for analysis of dioxins, furans and PCBs. The median (25th, 75th percentile) concentrations for total PCDDs, PCDFs and coplanar PCBs were 95.8 pg/g lipids (40.9, 144), 33.9 pg/g lipids (20.4, 61.8), and 120 pg/g lipids (77.6, 157), respectively. For WHO-TEQs, the median (25th, 75th percentile) for total PCDDs, PCDFs, and coplanar PCBs were 0.29 (0.1, 9.14), 7.98 (5.27, 12.3), and 7.39 (4.51, 11.9), respectively. Although TCDD was largely non-detectable, two boys had high TCDD levels (17.9 and 21.7 pg/g lipid). Higher serum levels of sum of dioxin-like compounds and sum of dioxin TEQs were positively associated with increased age, consumption of fish, local meats other than chicken, PCB 118, and inversely with weeks of gestation. The total TEQs among Chapaevsk adolescents were higher than most values previously reported in non-occupationally exposed populations of comparable or even older ages. Dietary consumption of local foods, as well as age and weeks of gestation, predicted dioxin exposure in this population.
    Environmental Health 02/2005; 4(1):8. DOI:10.1186/1476-069X-4-8 · 3.37 Impact Factor
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    • "Comparison of PCB congener profiles in blood (Wuthe et al., 1996), human milk (WHO, 1996), and follicular fluid (this work). For each matrix, congener concentrations have been normalized with respect to the most abundant congener (PCB 153). "
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    ABSTRACT: Based on observations in animals, there is an increasing evidence that a number of persistent organochlorine pollutants can alter the endocrine homeostasis, this resulting in toxic effects in particular in the developing organism. However, the role of these chemicals in determining endocrine-related diseases in humans, and possibly a decrease of fertility, is still controversial. Exposure data concerning the human reproductive system are essential for risk assessment. Based on this, the occurrence in follicular fluid of polychlorobiphenyls (PCBs), 2,3,7,8-chlorosubstituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT) and its metabolites, and hexachlorobenzene (HCB) was investigated. With respect to PCBs, the sum of the three most abundant congeners (PCBs 138, 153 and 180) was 1230 ng/g, lipid basis (0.37 ng/g, wet weight). Congener distribution profile overlapped what is usually observed in other human tissues, as blood and milk. PCDDs, PCDFs, p,p'-DDT and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDD) were below their determination limits. 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE) and HCB were detected in concentrations respectively in the order of 700 and 70 ng/g, lipid basis (approximately 0.2 and approximately 0.02 ng/g, wet weight).
    Chemosphere 04/2004; 54(10):1445-9. DOI:10.1016/j.chemosphere.2003.10.040 · 3.34 Impact Factor
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    ABSTRACT: Question. In face of the global distribution of polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB), regional differences in the human burden with these substances are anticipated and could be demonstrated in animal research as well as in humans in a global context. It was the aim of the present study to investigate whether there are any regional differences in the prenatal burden with PCBs and HCB in a rural vs. metropolitan area in Germany. Patients and methods. Each 100 full-term healthy newborns were recruited who were born in Fulda and Düsseldorf, respectively, in 1998. A blood sample was taken from each newborn within the first hours of life, in every case before the first oral feeding. Six PCB congeners (28, 52, 101, 138, 153, and 180) as well as HCB were determined in serum with capillary gaschromatography with ECD-detection. The results of both study groups were tested on mean differences with Wilcoxon's test for independent samples. Results. There were no statistically significant differences between both study groups with regard to gestational age, birth weight and maternal age. The same applied to the three detectable, higher-chlorinated PCB congeners 138, 153, and 180. Only HCB concentration was significantly higher in the newborns from Düsseldorf as compared with those from Fulda (0.26 vs. 0.16 μg/l). Conclusions. We could not demonstrate evidence for obvious differences in the prenatal burden with PCBs in two defined regions of Germany today. On the other hand, neonates born in a metropolitan area have significantly higher HCB concentrations than newborns from a rural area. Possible explanations for this finding are discussed. It is suggested that these differences will be evened out in the next years according to the general decline in the neonatal burden with these organochlorine compounds in Germany.
    Monatsschrift Kinderheilkunde 03/2001; 149(3):283-287. DOI:10.1007/s001120050762 · 0.23 Impact Factor
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