A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families.

Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Schizophrenia Research (Impact Factor: 4.59). 11/1996; 22(1):61-8. DOI:10.1016/0920-9964(96)00048-5
Source: PubMed

ABSTRACT Two recent genome-wide searches for linkage (Lasseter et al., 1994; Moises et al., 1995) suggested that a susceptibility gene for schizophrenia might be located at chromosome 8p21-p22. We attempted to replicate these findings by performing a linkage study of schizophrenia with four DNA markers from this region using 25 multiply affected families. Neither the lod score method nor non-prametric extended sib-pair analysis yielded any evidence for linkage, even under the assumption of locus heterogeneity. We conclude that there is unlikely to be a major gene in the 8p21-p22 region which confers susceptibility to schizophrenia in our set of families. However we cannot exclude the possibility of a major gene present in other families, or of a susceptibility gene with a moderate but widespread effect which we cannot detect.

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