Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia

Laboratoire de Physiologie, Faculté de Pharmacie, Université René Descartes, Paris, France.
Neuropeptides (Impact Factor: 2.64). 09/1996; 30(4):355-8. DOI: 10.1016/S0143-4179(96)90024-4
Source: PubMed


The beneficial effects of exogenous kappa receptor agonists in preventing neuronal damage elicited by brain ischemia suggest a role for endogenous dynorphins. In agreement prodynorphin (PDYN) gene expression in granule cells of the dentate gyrus detected by in situ hybridization was drastically but transiently decreased 18-32 h after four-vessel cerebral ischemia for 20 min in rats. We propose that decreased dynorphin synthesis and release could contribute to the delayed neuronal death of hippocampal pyramidal cells in this model.

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