Article

[The APC gene].

Department of Oncogene Research, Osaka University.
Nippon rinsho. Japanese journal of clinical medicine 05/1996; 54(4):955-9. pp.955-9
Source: PubMed

ABSTRACT The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in cell adhesion. More recently we have demonstrated that overexpression of APC blocks cell cycle progression from the G0/G1 to the S phase.

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Keywords

300 kDa protein present
 
adherence junction protein catenin
 
APC
 
APC blocks cell cycle progression
 
APC gene
 
APC protein
 
familial adenomatous polyposis
 
S phase
 
tumor suppressor gene APC