Correlation between peripapillary atrophy and optic nerve damage in normal-tension glaucoma.
ABSTRACT To investigate the correlation between peripapillary atrophy and visual field defects as well as optic nerve head configurations in patients with normal-tension glaucoma (NTG).
Topographic measurements for peripapillary atrophy and optic nerve head using confocal scanning laser tomography and automated static threshold perimetry were performed on 102 eyes of 51 patients with NTG. Peripapillary atrophy was divided into (1) a central zone (zone Beta) with visible, large choroidal vessels and sclera, and (2) a peripheral zone (zone Alpha) with irregular hyper- and hypopigmentation. The area, angular extent around the disc, and radial extent of each zone were measured.
The area and extent of zone Beta increased significantly with increasing visual field defects expressed in terms of mean deviation, corrected pattern standard deviation, central visual field defects within 5 degrees of fixation, and superior hemifield defects (r = 0.3770-0.5291, P < 0.01). The angular extent of zone Beta represented localized field defects better (r = 0.5217, P < 0.001) than diffuse field defects (r = -0.3770, P < 0.01). Zone Beta significantly correlated with optic nerve head topography. Intraindividual right-left-side differences of corrected pattern standard deviation showed the highest correlation with the side differences of zone Beta area (r = 0.6305, P < 0.001). The location of visual field defects correlated significantly with the location of peripapillary atrophy (chi-square = 9.0484, P = 0.011). Zone Alpha was not significantly correlated with visual field defects or optic nerve head configurations (P > 0.05).
Peripapillary atrophy is significantly associated with functional and structural optic nerve damage in NTG.
- SourceAvailable from: Kuldar Kaljurand[Show abstract] [Hide abstract]
ABSTRACT: To examine the frequency of exfoliation syndrome (XFS) in Estonian patients scheduled for cataract surgery. A series of 305 patients (mean age 71.5 +/- 8.6 years) scheduled for cataract surgery were examined for the presence of exfoliation syndrome, predominant type of lens opacification and intraocular pressure (IOP). Exfoliation material was detected in 108 (35.4%) patients, of whom 51 (47.2%) were bilaterally and 57 (52.8%) were unilaterally affected. In the bilaterally phakic patients exfoliation material was detected in 92 (30.2%) patients, of whom 51 (55.4%) were bilaterally and 41 (44.6%) were unilaterally affected. Intraocular pressure was higher in eyes with exfoliation than in eyes without it (19.2 +/- 6.5 mmHg and 17.1 +/- 3.8 mmHg, respectively; p = 0.006). Nuclear sclerosis predominated in eyes with XFS compared to those without XFS (57.6% and 36.9%, respectively). Cortical (7.6%) and subcapsular (7.6%) cataracts were less common in eyes with XFS than in eyes without XFS (16.9% and 20.2%, respectively). Mature cataract was found in 41.3% of all mixed types of cataracts. Exfoliation syndrome is common in Estonian patients. It was detected in 35.4% of the patients scheduled for cataract surgery.Acta Ophthalmologica Scandinavica 07/2004; 82(3 Pt 1):259-63. DOI:10.1111/j.1600-0420.2004.00256.x · 1.85 Impact Factor
- Spektrum der Augenheilkunde 05/2009; 23(3):209-212. DOI:10.1007/s00717-009-0327-8 · 0.18 Impact Factor
Article: Ophthalmology ROUNDS[Show abstract] [Hide abstract]
ABSTRACT: Welcome to the inaugural issue of Ophthalmology Rounds from the Massachusetts Eye and Ear Infirmary. This issue starts with a description of a woman with symptoms that appear to indicate a diagnosis of glaucoma, a common scenario for the eyecare practitioner. The following sections describe the characteristic features associated with this diagnosis and the comprehensive steps required to perform a systematic optic nerve examination. The issue subsequently returns to the case, with an elucidation of the patient's diagnosis and a detailed description of the epidemiology, clinical features, treatment options and prognosis for patients with this problem.