Lesions of the lateral parabrachial nucleus block the aversive motivational effects of both morphine and morphine withdrawal but spare morphine's discriminative properties.
ABSTRACT This study examined if the aversive properties of morphine, the aversive properties of morphine withdrawal, and the discriminative properties of morphine are mediated by common neurobiological substrates. Lesions of the lateral parabrachial nucleus, which blocked the aversive properties of morphine in the conditioned taste aversion paradigm, also blocked the acquisition of conditioned place aversions to environments paired with the aversive properties of morphine withdrawal in morphine-dependent rats. When morphine and saline were used as cues in a discrimination task, however, both sham-operated and lesioned rats were able to solve the task.
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ABSTRACT: The parabrachial complex has been related to various rewarding or aversive behavioral processes, including taste aversion learning and conditioned place aversion. This study examined the effect of tiapride, an antagonist of D2/D3 dopaminergic receptors, on place aversion induced by electrical stimulation of the external lateral parabrachial (LPBe) nucleus. Results obtained show that brain-stimulated animals avoid the area of the maze associated with electrical stimulation but show no such behavioral rejection when they receive an injection of 30 mg/kg tiapride. Furthermore, tiapride did not appear to affect the horizontal motor activity (crossing) of the animals. These results are discussed in the context of the different natural and artificial modalities used to induce aversive behavior and their relationship with dopamine systems.Acta neurobiologiae experimentalis 01/2014; 74(3):307-16. · 1.98 Impact Factor
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ABSTRACT: The lateral parabrachial complex has been related to various emotional-affective processes. It has been shown that electrical stimulation of the external lateral parabrachial (LPBe) nucleus can induce reinforcing effects in place preference and taste discrimination tasks but does not appear to support self-stimulation. This study examined the relative relevance of place and taste stimuli after electrical stimulation of the LPBe nucleus. A learning discrimination task was conducted that simultaneously included both sensory indexes (taste and place) in order to determine the preference of animals for one or the other. After a taste stimulus reversal task, the rewarding effect of stimulation was found to be preferentially associated with place. These results are discussed in the context of the rewarding action and biological constraints induced by different natural and artificial reinforcing agents.Neurobiology of Learning and Memory 01/2013; · 3.33 Impact Factor
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ABSTRACT: Ghosts in ultrasonic measurement with a sparse phased array are effectively suppressed by combining directivity patterns using two frequencies. The two-frequency ultrasonic measurement can be realized by tuning the resonant frequency of piezoelectric microsensors composing the array. Piezoelectric tunable resonant microsensors have been fabricated for the measurement technique. The resonant frequency has been controlled adequately to switch between a base frequency and a lower sub-frequency of 57% to the base frequency on the fabricated sensor. The frequency switching enables the sparse phased array in the twofrequency measurement to suppress ghosts by decreasing sidelobe level from 134% to 10% compared to the conventional single frequency measurement.Procedia Engineering. 01/2010; 5:754-757.