Lesions of the lateral parabrachial nucleus block the aversive motivational effects of both morphine and morphine withdrawal but spare morphine's discriminative properties.
ABSTRACT This study examined if the aversive properties of morphine, the aversive properties of morphine withdrawal, and the discriminative properties of morphine are mediated by common neurobiological substrates. Lesions of the lateral parabrachial nucleus, which blocked the aversive properties of morphine in the conditioned taste aversion paradigm, also blocked the acquisition of conditioned place aversions to environments paired with the aversive properties of morphine withdrawal in morphine-dependent rats. When morphine and saline were used as cues in a discrimination task, however, both sham-operated and lesioned rats were able to solve the task.
- SourceAvailable from: ufrsdv.u-bordeaux2.fr5 11/2004; Academic Press.
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ABSTRACT: The main objective of this book is to create a compendium of the methods currently used to assess drug reinforcement by providing synopses of these diverse procedures in a single reference. Each of the major methods of studying drug reinforcement has been summarized, and applications of these techniques are illustrated. Although the specific applications of these methods may vary, the methodological considerations outlined in this book should provide a lasting framework for interpreting the results of current experimental findings. (PsycINFO Database Record (c) 2012 APA, all rights reserved)Behavioural Pharmacology - BEHAV PHARMACOL. 1(2).
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ABSTRACT: The column summarizes articles from Nature that deal with issues related to water quality, pollution and resource management, as well as a scientific breakthrough for the synthesis of zeolite materials.Nature 01/1996; 382:665. · 38.60 Impact Factor