Article

Radioprotective effect of whole-body hyperthermia on mice exposed to lethal doses of total-body gamma irradiation.

Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Indian journal of experimental biology (impact factor: 1.29). 10/1996; 34(9):842-4. pp.842-4
Source: PubMed

ABSTRACT The whole-body hyperthermia (40 degrees C, 1 hr) 20-48 hr prior to total-body irradiation (TBI) with 9 Gy gamma rays gave 80% protection as assessed by survival of the animals. However this was reduced to 50% when mice were irradiated 7 or 15 days after hyperthermia. The local hyperthermia (42 degrees C, 1 hr) given prior to irradiation, on the other hand, did not show any protective effect. The whole-body or local hyperthermia given after TBI had no protective effect on survival of animals.

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Keywords

40 degrees C
 
42 degrees C
 
80% protection
 
9 Gy gamma rays
 
hyperthermia
 
local hyperthermia
 
protective effect
 
total-body irradiation
 
whole-body
 
whole-body hyperthermia