Hepatitis C virus among health care workers

Institute of Public Health and Social Medicine, University Federico II, Naples.
Minerva medica (Impact Factor: 0.91). 12/1996; 87(11):501-4.
Source: PubMed


The purpose of our study was to describe the results of a seroprevalence survey for HCV antibody among health care workers at our center. 961 specimens were consecutively obtained under code and screened for anti-HCV by the second generation immunoblot assay (RIBA 2) and hepatitis B core antibody by CORAB test. After serum samples were tested, we reviewed demographic data and categorized four groups: intravenous drug abusers (IVDAs), blood recipients, health care workers and apparently healthy subjects. 51/97 (52.6%) IVDAs, 8/77 (10.4%) transfusion recipients, 12/472 (2.5%) health care workers and 8/285 (2.8%) apparently healthy subjects were anti-HCV positive. Furthermore dividing health care personnel by type of profession we found that surgeons have a higher seroprevalence (4.3%) compared to other professions. Therefore severe preventive standards are required for health care workers.

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    • "Klein et al (1991) found significantly more dentists (1.7%) than blood donors (0.14%) to be seropositive for HCV, the highest rate (9%) was seen among oral surgeons. Higher prevalence rates have been reported for surgeons (4.3%) (DeMercato et al, 1996) and for health care workers involved with liver transplantation (5.3%) (Goetz et al, 1995) or working in internal medicine, pathology, or intensive care units (up to 7.1%) (Mihaly et al, 1996). The most important risk factor appears to be unintentional needlestick injury, and transmission of HCV by this route has been confirmed using sequence comparisons of HCV isolates (Mizuno et al, 1997; Suzuki et al, 1994). "
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    ABSTRACT: Hospital-related hepatitis C virus (HCV) infections continue to occur even after the introduction of blood donor screening. We report an outbreak of HCV in nine patients of a pediatric oncology ward in 1996/1997. Sequencing of the hypervariable genomic region 1 (HVR1) of the E2/NS1 region showed near identity between HCV isolates from these patients as evidence for infection with the same virus. Despite a detailed and careful investigation, the source of infection and the mode of virus transmission could not be established. Based on a review of the current literature about nosocomial HCV infection and HCV infection in children, hypotheses for possible means of transmission in this outbreak are discussed.
    Laboratory Investigation 04/2001; 81(3):251-62. DOI:10.1038/labinvest.3780234 · 3.68 Impact Factor
  • American Journal of Infection Control 11/2004; 32(6):375-6. DOI:10.1016/j.ajic.2004.03.008 · 2.21 Impact Factor
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    ABSTRACT: Hepatitis C virus (HCV) is a parenterally transmitted virus that poses an occupational hazard to the health care workers (HCWs). No significant data are available regarding the prevalence of HCV in health care workers in India. The present study was designed to determine the seroprevalence of HCV infection in health care workers in a tertiary care centre in New Delhi. The subjects (n=100) were divided according to the duration of employment and the unit where they were working. Blood samples were collected from all the subjects and sera were tested for anti-HCV antibodies. The seroprevalence of anti-HCV was found to be 4 per cent. The duration of occupational exposure was not a significant risk factor for HCV infection and prevalence of anti-HCV antibodies were highest in HCWs working in haemodialysis units. The seroprevalence of HCV in health care workers was considerably higher than that reported in the general population, and needs to be evaluated on a larger sample.
    The Indian Journal of Medical Research 03/2006; 123(2):179-80. · 1.40 Impact Factor
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