Article

An investigation of polymorphism in the interleukin-10 gene promoter.

Tissue Typing Laboratory, St Mary's Hospital, Manchester, UK.
European Journal of Immunogenetics 03/1997; 24(1):1-8. DOI: 10.1111/j.1365-2370.1997.tb00001.x
Source: PubMed

ABSTRACT Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

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