Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver

Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago, Chile.
General Pharmacology 04/1997; 28(3):361-4. DOI: 10.1016/S0306-3623(96)00231-5
Source: PubMed


Microsomal lauric acid hydroxylation and fatty acid peroxisomal beta-oxidation were studied in hepatic subcellulant preparations from streptozotocin-induced diabetic and diabetic insulin-treated rats. 2. The liver microsomes of the streptozotocin diabetic rats displayed a similar activity to hydroxylate lauric acid as the control microsomes. 3. Diabetic insulin-treated rats showed lower (omega 1) and omega-lauric acid hydroxylase activities than diabetic and control rats. 4. Streptozotocin-induced diabetes and diabetic insulin-treated rats exhibited no significant changes on peroxisomal palmitoyl CoA beta-oxidation compared to the control rats. 5. Both microsomal and peroxisomal fatty acid oxidation responded in a similar way in this model of experimental diabetes.

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