Influence of Bilirubin on the Antioxidant Capacity of Plasma in Newborn Infants
ABSTRACT In vitro, bilirubin is a strong antioxidant, but in vivo its capacity to act as a scavenger of toxic oxygen radicals remains poorly documented. The aim of this study was to evaluate of bilirubin had antioxidant properties in jaundiced infants. The antioxidant capacity of neonatal plasma was measured in Trolox equivalents (TEAC, mmol/l) and correlated in vitro with plasma bilirubin concentrations (r2 = 0.99). Plasma TEAC was compared before and after exchange transfusions for neonatal hyperbilirubinemia (250-435 mumol/l). The antioxidant properties of the paired blood samples before and after exchange transfusions (TEAC: 1.67 +/- 0.12 vs. 1.37 +/- 0.09 mmol/l, n = 11) varied in proportion to the serum bilirubin levels. The changes in other antioxidants were not large enough to account for the magnitude of change in antioxidant capacity. Therefore, in vivo, the plasma antioxidant capacity of jaundiced newborn infants is related to the level of bilirubin.
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- "Three isoforms of HO have been identified: both HO-2 and HO-3 are 33-kDa constitutively expressed isoforms . An important role of HO-1 in the antioxidant defense system arises from an induction of ferritin synthesis that diminishes the cellular pool of free iron  and also from the enhancement of bilirubin levels, which are potent antioxidants . Carbon monoxide activates soluble guanylate cyclase, a key enzyme in the cell signaling cascade leading to relaxation of smooth muscle, and thrombocyte disaggregation. "
Article: Exercise and the Aging Endothelium[Show abstract] [Hide abstract]
ABSTRACT: The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponential mortality rates from vascular disease such as myocardial infarction and stroke that occurs in the ageing population. There are a number of mechanisms suggested to explain age-related endothelial dysfunction. However, recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases. Regular physical activity, known to have a favorable effect on cardiovascular health, can also improve the function of the ageing endothelium by modulating oxidative stress and inflammatory processes, as we discuss in this paper.Journal of Diabetes Research 08/2013; 2013:789607. DOI:10.1155/2013/789607 · 3.54 Impact Factor
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- "In the late 1980s, Ames and colleagues ( ) demonstrated that the antioxidant effect of bilirubin exceeds that of vitamin E toward lipid peroxidation. Serum concentrations of bilirubin are high enough to account for a substantial portion of the total antioxidant capacity of serum ( ). "
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- "Three isoforms of HO have been identified: both HO-2 and HO-3 are 33-kDa isoforms that are expressed constitutively . The important role of HO-1 in the antioxidant defense system arises from an induction of ferritin synthesis that diminishes the cellular pool of free iron  and also from the enhancement of bilirubin levels, which are potent antioxidants . Carbon monoxide activates soluble guanylate cyclase, a key enzyme in cell signaling that leads to vasodilation, relaxation of smooth muscle, and thrombocyte disaggregation. "
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