Terbinafine therapy may be associated with the development of psoriasis de novo or its exacerbation: four case reports and a review of drug-induced psoriasis.
ABSTRACT Adverse effects may occur in 10.4% of patients receiving terbinafine therapy, with cutaneous reactions in 2.7%. We describe the development of psoriasis in four patients who took oral terbinafine. Two patients had plaque-type psoriasis that flared 12 and 17 days, respectively, after starting terbinafine. Another patient developed pustular-type psoriasis de novo after 27 days of terbinafine therapy. The fourth patient was a psoriatic with stable plaque disease who experienced a pustular flare after taking terbinafine for 21 days. We are aware of only one report in the literature in which a patient developed pustular psoriasis de novo after 5 days of terbinafine therapy. In all patients the psoriasis cleared or lessened after discontinuation of terbinafine and institution of antipsoriatic therapy.
- SourceAvailable from: Jana KazandjievaClinics in Dermatology 05/1998; 16(3). · 1.93 Impact Factor
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ABSTRACT: It remains unclear whether or not creating gaps in planted forests can increase the plant species composition, structure, and biodiversity, and also whether it can be helpful for restoring planted forests (to a more natural state). Based on a comparison of species composition and structure among forest patches, small gaps (4–25m2), medium gaps (25–150m2) and large gaps (150–450m2), we found that (1) creating gaps enhanced vascular plant diversity. Both the species richness and Shannon diversity indices of small, medium and large gaps were significantly higher than in the understory. The pattern of increasing diversity of vascular plants with gap creation could be partly attributed to the emergence of novel shade intolerant species in gaps. (2) Creating gaps favored the colonization and regeneration of native species. Gap size influenced not only the emergence and density of individuals of different species, but also the emergence of different life form types. Small gaps promoted the regeneration of some shrub species, such as Ostryopsis davidiana, Rosa hugonis, and Forsythia suspense, leading to these species becoming canopy dominants early on in succession. The medium and large gaps favored the growth of tree species, such as Populus davidiana and Betula platyphylla (early successional stage), and Quercus liaotungensis and Pinus tabulaeformis (later successional phase). (3) The canonical correspondence analysis showed that plant species composition and distribution were mainly influenced by gap size and slope aspect, and that the recorded plant species could be divided into three life forms (trees, shrubs and herbs) on the biplot diagram. (4) Finally, creating gaps provided opportunities not only for native pioneer species in the early successional stage, but also for climatic climax species to grow to canopy dominants in later successional phases, suggesting that a more natural forest will develop with plant succession. Gap size plays an important role in plant regeneration, and it could be used to produce desired successional communities in near natural management for planted forests.Fuel and Energy Abstracts 08/2011; 262(3):413-423.
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ABSTRACT: The patients clinically diagnosed with psoriasis were investigated for drug use that may trigger psoriasis.Postepy Dermatologii I Alergologii 10/2014; 31(5):294-8. · 0.66 Impact Factor