Article

Substance abuse and schizophrenia: editors' introduction.

Yale University School of Medicine, West Haven, CT, USA.
Schizophrenia Bulletin (Impact Factor: 8.61). 02/1997; 23(2):181-6. DOI: 10.1093/schbul/23.2.181
Source: PubMed

ABSTRACT Most individuals with schizophrenia have problems with abuse of substances ranging from licit substances, such as nicotine, to illicit ones, such as cocaine. This comorbidity may reflect self-medication, as well as a biological susceptibility to both disorders. Twin studies have suggested that this biological susceptibility may involve genetic factors. Other biological risk factors may involve the medications used to treat schizophrenia, which may produce symptoms that provoke abuse of drugs to relieve negative symptoms or may even enhance the euphoric response to abused drugs. The articles in this issue address several research areas related to substance abuse and schizophrenia, including the differential diagnosis of schizophrenia and organic disorders induced by substance abuse and the impact of substance abuse on the course of early schizophrenia. The management of substance-abusing schizophrenia patients requires a careful balance of pharmacotherapy and psychotherapies, and atypical antipsychotic agents may be particularly helpful. Psychotherapy needs to focus both on the management of affect and on the adequate monitoring of drug abstinence.

0 Followers
 · 
49 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Schizophrenia has a high natural mortality of a largely environmental aetiology. There is, however, little research about possible risk factors. This study measured the diet, cigarette and alcohol use, exercise and obesity of a cohort of people with schizophrenia and compared results to general population rates. Semi-structured interview using validated research instruments on 102 middle-aged subjects with a diagnosis of schizophrenia, living in the community. Results were compared to general population norms using standard statistical tests. The subjects ate a diet higher in fat and lower in fibre than the general population. They look little exercise but were not significantly more obese. They smoked heavily but drank less alcohol. Most differences remained significant after controlling for social class. People with schizophrenia have an unhealthy lifestyle, which probably contributes to the excess mortality of the disease. They are therefore an appropriate target group for health promotion interventions.
    Psychological Medicine 06/1999; 29(3):697-701. DOI:10.1017/S0033291798008186 · 5.43 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Drivers’ drugs consumption in Peru, beside alcohol, constitutes a health problem and a not well-known risk condition to considerable traffic accidents. In Febrary 2005, it was made a transversal descriptive research by survey of one aleatory sample to 400 bus drivers, whose units pass by Tupac Amaru Avenue in the North Cone of Lima, Peru. To 150 drivers’ aleatory sub-samples, there were practiced urine analyses to detect ilegal drugs consumption (cocaine, marijuana and ecstasy). 60.5% and 89.4% of the drivers referred they have consumed alcoholic drinks in the last month and in the last year. 87.6% consume 1 or 2 times a month, 11.3% 1 or 2 times a week. The more alcohol consumer group corresponded to the younger drivers (25 to 29 years old, actual consumption: 78.1%) and also the minibus drivers (80.9%). Between the ones that drive after consuming any alcoholic drink, one of each five were involved in any road accident. The prevalency of drugs in asked drivers was: alcohol: 93.4%, marijuana: 10.8%, cocaine basic paste: 5.2%, cocaine hydrochlorate: 4.5%, ecstasy: 0%. The urine analysis revealed positive to cocaine consumption in 2.25% of the drivers. There were not found positive cases of marijuana and ecstasy in studied population.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Co-occurring substance use in psychotic patients causes many subsequences including increased illness severity, decreased medication compliance, higher relapse rates, more hospitalizations, and legal problems. We aim to investigate the prevalence, patterns, associated factors and severity of substance use risk among psychotic patients in southern Thailand. Psychotic out-patients were screened with the Alcohol, Smoking, Substance Involvement Screening Test (ASSIST) for their history of substance use in the past three months and categorized as None-to-Low Risk (NLR) or Moderate-to-High Risk (MHR) levels. Multivariate logistic regression was used to examine the associated factors of substance use risk-level. The associations between substance use risk-level and emotional and behavioural symptoms, functional status and family functional status were examined using multivariate linear regression analysis. Of 663 participants screened, 322 (48.6%) used at least one substance in the past three months. Tobacco was the most common substance used (47.2%). The factors associated with a higher risk of any substance use were male gender, young age group, low level of education, being employed and being diagnosed with schizophrenia. A higher number of emotional and behavioural symptoms was significantly associated with higher substance use risk-level. In conclusion, the prevalence of substance use in psychotic patients was high and associated with their emotional and behavioural symptoms. Recommendations for implementation of screening and early intervention programs of substance-related problems in psychotic patients are important for preventing unwanted outcomes.
    Asian Journal of Psychiatry 11/2014; 13. DOI:10.1016/j.ajp.2014.11.006