"Further progress with regard to drug safety was achieved by the development of the antihistamines cetirizine, fexofenadine, and descarboxyloratadine, which are cytochrome P450-independent metabolites of earlier antihistamines . The highest reported accidental overdose of antihistamine (50-fold of the prescribed dose of cetirizine in an 18-mo-old boy) induced no adverse effects other than sleepiness (Ridout and Tariq, 1997). The main drug interactions have been described until recently for sedating antihistamines in association with drugs affecting the central nervous system like analgetics, hypnotics, sedatives, and mood elevating drugs, as well as alcohol. "
[Show abstract][Hide abstract] ABSTRACT: This consensus report is the result of a panel discussion during the International Clinically Oriented ESDR Symposium Urticaria 2000. Urticaria has a profound impact on the quality of life and effective treatment is required. The most important are nonsedating H1 antihistamines. They have been proven to be effective in double-blind controlled studies, but concentrations higher than those recommended may be necessary. Due to different urticaria subtypes and the individual variation in the course of the disease and response to treatment, however, alternative therapies may be required. Immunosuppressive drugs like cyclosporine A and corticosteroids should not be used long term due to undesirable side-effects.
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