Cetirizine overdose in a young child

Journal of Allergy and Clinical Immunology (Impact Factor: 11.48). 07/1997; 99(6 Pt 1):860-1. DOI: 10.1016/S0091-6749(97)80028-0
Source: PubMed
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    • "Further progress with regard to drug safety was achieved by the development of the antihistamines cetirizine, fexofenadine, and descarboxyloratadine, which are cytochrome P450-independent metabolites of earlier antihistamines . The highest reported accidental overdose of antihistamine (50-fold of the prescribed dose of cetirizine in an 18-mo-old boy) induced no adverse effects other than sleepiness (Ridout and Tariq, 1997). The main drug interactions have been described until recently for sedating antihistamines in association with drugs affecting the central nervous system like analgetics, hypnotics, sedatives, and mood elevating drugs, as well as alcohol. "
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