Molecular typing of HLA class II DR antigens in indian kala azar patients

Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
Tropical Medicine & International Health (Impact Factor: 2.33). 06/1997; 2(5):468-71. DOI: 10.1016/0198-8859(96)85378-X
Source: PubMed


HLA has been shown to be associated with many diseases. To find out whether host genetic factors like the HLA are involved in susceptibility to kala-azar (visceral leishmaniasis) in India, we formulated an association study with genetically related controls. All samples were typed by PCR SSOP (sequence specific oligonucleotide probes) for HLA class I (A and B) and class II (DR) antigens. The test of association we used was the transmission disequilibrium test (TDT). No significant evidence for association with any of the three HLA loci was obtained.

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