Article

Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli

University of Rochester, Rochester, New York, United States
Gastroenterology (Impact Factor: 13.93). 09/1997; 113(2):659-63. DOI: 10.1053/gast.1997.v113.pm9247488
Source: PubMed

ABSTRACT Gastric adenocarcinoma has been previously recognized as a potential complication of familial adenomatous polyposis coli (APC) and attenuated forms of APC (AAPC). This tumor has only been reported to originate from adenomatous polyps of the gastric mucosa in these clinical conditions. There have been no previous case reports of gastric adenocarcinoma arising from the more commonly found fundic gland polyps associated with AAPC or APC. We report the first definitive case of gastric adenocarcinoma arising from a hyperplastic polyp of the fundis of a patient with AAPC.

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    ABSTRACT: Sklifasowski rapporterade 1881 det första säkra fallet av familjär adenomatös polypos (fap). Omvandlingen av en polyp till karci-nom beskrevs 1890 av Hanford. Den autoso-mala dominanta arvsgången beskrevs 1927 av Cockayne [1]. Gardner beskrev en släkt med polypos, multipla osteom och epidermoidcystor, vilket han ansåg vara en särskild genetisk sjukdom [2]. Sjukdomen kallas Gardners syndrom. Senare har desmoidtumörer och tandmiss-bildningar fogats till sjukdomsbilden. Gard-ners syndrom anses emellertid vara en variant av samma genetiska sjukdom där olika mani-festationer av fap uppträder utanför tarmen. Alm publicerade 1975 de första resultaten av behandling av familjär polypos på basis av det första nationella registret [3, 4]. Herrera och medarbetare upptäckte 1986 en deletion i den långa armen av kromo-som 5 hos en patient med Gardners syn-drom [5]. Följande år lokaliserades fap-lokuset med kopplingsanalys till regionen 5q21-22 [6]. apc-genen (adenomatous po-lyposis coli) lokaliserades 1991 och dess sekvens klargjordes [7, 8].