Resistance to activated protein C due to factor V R506Q mutation as a cause of venous thrombosis.

Department of Clinical Chemistry, Lund University, University Hospital, Malmö, Sweden.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion (Impact Factor: 0.31). 06/1997; 49 Suppl 1:3-5.
Source: PubMed
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    • "Similarly, coexistence of FVL and PC deficiency has 3 to 7-fold more risk of VTE than either of the two defects alone (Hallam et al, 1995; Zama et al, 1996; Koeleman et al, 1997, Jadaon & Dashti, 2005b). Moreover, more than half of patients with both APC-R and genetic PS deficiency were found to have thrombosis (Garcia de Frutos & Dahlbäck, 1995; Koeleman et al, 1997). It is interesting to mention here that a few isolated cases were reported to be double heterozygous for FVL and factor V deficiency, the mutations being present on opposite chromosomes. "
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