Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.

Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington 47405, USA.
Development (Impact Factor: 6.27). 10/1997; 124(17):3283-91.
Source: PubMed

ABSTRACT Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis. We find that partitioning of these fates is dependent on Delta-mediated signalling from 22 to 30 hours after puparium formation at 25 degrees C. Within the provein, Delta is expressed more highly in central provein cells (presumptive vein cells) and Notch is expressed more highly in lateral provein cells (presumptive intervein cells). Accumulation of Notch in presumptive intervein cells is dependent on Delta signalling activity in presumptive vein cells and constitutive Notch receptor activity represses Delta accumulation in presumptive vein cells. When Delta protein expression is elevated ectopically in presumptive intervein cells, complementary Delta and Notch expression patterns in provein cells are reversed, and vein loss occurs because central provein cells are unable to stably adopt the vein cell fate. Our findings imply that Delta-Notch signalling exerts feedback regulation on Delta and Notch expression during metamorphic wing vein development, and that the resultant asymmetries in Delta and Notch expression underlie the proper specification of vein and intervein cell fates within the provein.

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Available from: Stacey S Huppert, Jul 28, 2015
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    • "In the eye, cells along the dorsal side of the midline co-express N and Dl while their counterparts along the ventral side of the midline co-express N and Ser. Similar receptorligand relationships are also seen in the developing wing and are thought to mediate a positive-feedback loop between cells that straddle the D/V border (Diaz-Benjumea, 1995; Huppert et al., 1997). In the eye the model is that Ser expression in the ventral compartment signals across the midline to induce Notch-dependent activation of Dl transcription. "
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