Article

ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.

University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom.
American journal of mental retardation: AJMR (impact factor: 2.51). 10/1997; 102(2):103-10. DOI:10.1352/0895-8017(1997)102<0103:AGAADI>2.0.CO;2 pp.103-10
Source: PubMed

ABSTRACT The apoE gene polymorphism was examined in 100 adults with Down syndrome (with and without dementia) compared to 346 control subjects without mental retardation. Meta-analysis of available data (480 subjects) revealed that apolipoprotein E genotype distribution for people with Down syndrome was similar to that of the nonretarded population. Although no significant association between possession of the apoE epsilon 4 allele and onset of Alzheimer's disease was found, subjects with the allele had a tendency towards lower age of onset of dementia. Subjects with apoE epsilon 2 allele may not develop dementia and may have increased longevity.

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    Article: Down syndrome: advances in molecular biology and the neurosciences.
    G T Capone
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    ABSTRACT: The entire DNA sequence for human chromosome 21 is now complete, and it is predicted to contain only about 225 genes, which is approximately three-fold fewer than the number initially predicted just 10 years ago. Despite this remarkable achievement, very little is known about the mechanism(s) whereby increased gene copy number (gene dosage) results in the characteristic phenotype of Down syndrome. Although many of the phenotypic traits show large individual variation, neuromotor dysfunction and cognitive and language impairment are observed in virtually all individuals. Currently, there are no efficacious biomedical treatments for these central nervous system-associated impairments. To develop novel therapeutic strategies, the effects of gene dosage imbalance need to be understood within the framework of those critical biological events that regulate brain organization and function.
    Journal of Developmental & Behavioral Pediatrics 03/2001; 22(1):40-59. · 2.13 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

346 control subjects
 
Alzheimer's disease
 
apoE epsilon 2 allele
 
apoE epsilon 4 allele
 
apoE gene polymorphism
 
apolipoprotein E genotype distribution
 
available data
 
lower age
 
Meta-analysis
 
significant association