Article

Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion.

Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Developmental Brain Research (impact factor: 1.78). 10/1997; 102(2):291-3. pp.291-3
Source: PubMed

ABSTRACT It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a beta adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol + stroking and 6 mg/kg of isoproterenol + no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.

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    Reto Bisaz, Regina M Sullivan
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Keywords

1-week-old rat pups
 
5-HT2 receptors
 
beta adrenoceptor
 
bulbar 5-HT
 
bulbar response
 
induce normal odor preference
 
inverted-U curve relation
 
isoproterenol +
 
isoproterenol + stroking
 
olfactory bulb prime
 
pups
 
stroking