Article

Differential induction of superoxide dismutase in core and penumbra regions after transient focal ischemia in the rat neocortex.

Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville 22908, USA.
Neuroscience Letters (impact factor: 2.11). 11/1997; 235(1-2):29-32. DOI:10.1016/S0304-3940(97)00707-6 pp.29-32
Source: PubMed

ABSTRACT Oxygen free radicals are postulated to participate in the pathogenesis of ischemic brain injury. The present study investigated the response of the endogenous antioxidant enzyme, superoxide dismutase (SOD), in a model of transient focal ischemia in the rat neocortex. SOD activity was increased significantly in the penumbra region at 6-24 h postischemia, while no significant changes in SOD activity were observed in either the core region or striatum. These results indicate that endogenous antioxidant activity is differentially affected by the intensity of ischemic challenge and suggest that the regional effects of oxygen free radicals may vary substantially following ischemia-reperfusion.

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    Article: The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils.
    Vincenzo Mollace, Michelangelo Iannone, Carolina Muscoli, Ernesto Palma, Teresa Granato, Andrea Modesti, Robert Nisticò, Domenicantonio Rotiroti, Daniela Salvemini
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    BMC Pharmacology 07/2003; 3:8.
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    M E Ustün, A Duman, C O Oğun, H Vatansev, A Ak
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    ABSTRACT: To examine the effects of calcium antagonists nimodipine and magnesium sulfate (MgSO4) on tissue endogenous antioxidant levels, the authors studied superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rabbit brain 1 hour after experimental head trauma. Forty New Zealand rabbits were anesthetized and randomly divided into four groups. Group 1 (n = 10) was the sham operated group. Group 2 (n = 10), the control group, received head trauma and no treatment. Group 3 (n = 10) received head trauma and intravenous (IV) 2 microgr/kg nimodipine. Group 4 (n = 10) received head trauma and IV 100 mg/kg MgSO4. Head trauma was delivered by performing a craniectomy over the right hemisphere and dropping a weight of 20 g from a height of 40 cm. In the right (traumatized) hemisphere, SOD and GPx decreased by 57.60% +/- 9.60% and 72.93% +/- 5.51% respectively from sham values. Magnesium sulfate, but not nimodipine, reduced the magnitude of decrease of SOD and GPx to 19.43% +/- 7.15% and 39.01% +/- 7.92% respectively from sham values. In the left (nontraumatized) hemisphere, MgSO4 increased SOD to 42.43% +/- 24.76% above sham values. The authors conclude that MgSO4 treatment inhibited the decrease in SOD and GPx levels in experimental brain injury.
    Journal of Neurosurgical Anesthesiology 08/2001; 13(3):227-32. · 2.23 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

6-24 h postischemia
 
endogenous antioxidant activity
 
endogenous antioxidant enzyme
 
ischemia-reperfusion
 
Oxygen free radicals
 
pathogenesis
 
rat neocortex
 
significant changes
 
SOD
 
SOD activity
 
superoxide dismutase
 
transient focal ischemia
 

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