Folate economy in pregnancy

University of Bonn, Bonn, North Rhine-Westphalia, Germany
Nutrition (Impact Factor: 2.93). 11/1997; 13(11-12):975-7. DOI: 10.1016/S0899-9007(97)00340-7
Source: PubMed


Pregnant women are prone to becoming folate deficient because there is a significant increase in folate requirement during pregnancy and folate intakes of pregnant women are often insufficient. Reduced folate levels in blood and neutrophilic hypersegmentation reflect a negative folate balance. Possible consequences of a low maternal folate status may be pregnancy complications such as abortion, abortus imminens, abruptio placentae, and congenital malformations. The role of folic acid in the etiology of neural tube defects has been discussed for decades. The importance of an adequate maternal folate status in the prevention of neural tube defects has been demonstrated by observational and controlled intervention trials. However, the mechanism of the protective effect of periconceptional folate supplementation is not completely understood. Metabolic disorders are probably involved in the pathogenesis of neural tube defects so that a relative folate shortage rather than folate deficiency seems to be responsible for the disturbed neural tube development, which can be compensated for by a higher folate intake.

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    • "Folic acid has additional benefits on pregnancy. It can help to reduce the risk for congenital anomalies [23] [24] [25]. Folic acid is necessary for the production of red blood cells and the synthesis of DNA, which controls tissue growth and cell function. "
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    ABSTRACT: Reduced appetite and low food intake are often a concern in preschool children, since it can lead to malnutrition, a leading cause of impaired growth and mortality in childhood. It is occasionally considered that folic acid has a positive effect on appetite enhancement and consequently growth in children. The aim of this study was to assess the effect of folic acid on the appetite of preschool children 3 to 6 y old. The study sample included 127 children ages 3 to 6 who were randomly selected from 20 preschools in the city of Tehran in 2011. Since appetite was measured by linguistic terms, a fuzzy logistic regression was applied for modeling. The obtained results were compared with a statistical ordinal logistic model. After controlling for the potential confounders, in a statistical ordinal logistic model, serum folate showed a significantly positive effect on appetite. A small but positive effect of folate was detected by fuzzy logistic regression. Based on fuzzy regression, the risk for poor appetite in preschool children was related to the employment status of their mothers. In this study, a positive association was detected between the levels of serum folate and improved appetite. For further investigation, a randomized controlled, double-blind clinical trial could be helpful to address causality.
    Nutrition 03/2014; 30(3):274-278. DOI:10.1016/j.nut.2013.08.008 · 2.93 Impact Factor

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