Article

A short, stereoselective synthesis of (3R,4R)-4-acetoxy-3-[(R)-1'((t-butyldimethylsilyl)oxy)ethyl]-2-azetidin one, key intermediate for the preparation of carbapenem antibiotics.

Dipartimento di Chimica Organica e Industriale, Università di Milano, Italy.
Chirality (impact factor: 2.35). 02/1998; 10(1-2):91-4. pp.91-4
Source: PubMed

ABSTRACT A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active beta-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.

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Keywords

acetoxy azetidinone
 
available
 
biologically active beta-lactam antibiotics
 
short stereoselective synthesis