Article

Plasma interleukin-3 (IL-3) and IL-7 concentrations in children with homozygous beta-thalassemia.

Ege University, Medical School, Department of Pediatrics, Izmir, Turkey.
Journal of Tropical Pediatrics (impact factor: 1.39). 01/1998; 43(6):366-7. pp.366-7
Source: PubMed

ABSTRACT Plasma levels of IL-3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines are involved in abnormalities in erythropoiesis and immune responses as observed in thalassemic patients. No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not a cytokine involved in cellular immunological alterations in beta-thalassemia. However, the number of thalassemic patients with detectable IL-3 concentrations was significantly higher. It was concluded that IL-3 production has to be studied in detail in order to learn more about the involvement of this cytokine in erythropoiesis of thalassemic patients.

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Keywords

23 patients
 
beta-thalassemia
 
cellular immunological alterations
 
cytokines
 
detectable IL-3 concentrations
 
healthy controls
 
homozygous beta-thalassemia
 
IL-3
 
IL-3 production
 
IL-7
 
immune responses
 
plasma IL-7 concentrations
 
thalassemic patients
 

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