11q13 Allelotype Analysis in 27 Northern American MEN1 Kindreds Identifies Two Distinct Founder Chromosomes
ABSTRACT We analyzed constitutional and tumor DNA from 27 MEN1 kindreds not known to be related to each other. Disease allele haplotypes were constructed for each pedigree based on shared alleles from two or more affected members and from determination of allelic loss patterns in their tumors. Analysis of disease allele haplotypes showed unexpected linkage disequilibrium at marker PYGM. Further haplotype analysis indicated this could be explained by the presence of two founder chromosomes, one in four families, the other in three. A shared disease haplotype was not observed among two MEN1 kindreds with the prolactinoma phenotype of MEN1.
SourceAvailable from: Alberto Falchetti
Article: Psychological License[Show abstract] [Hide abstract]
ABSTRACT: Differences among people in the actions they take or the opinions they express do not always reflect differences in underlying attitudes, preferences, or motivations. When people differ in the extent to which they are psychologically licensed (i.e., feel able to act without discrediting themselves), they will act differently despite having similar attitudes, preferences, and motivations. Wanting to do something is not sufficient to spur action; one must also feel licensed to do it. We show that feeling licensed can liberate people to express morally problematic attitudes that those who do not feel licensed are inhibited from expressing. We also show that feeling one lacks license can inhibit people from expressing even morally nonproblematic attitudes that those who feel licensed are comfortable expressing. This chapter explores a wide range of social phenomena in which licensing plays a role and identifies a number of variables that grant or revoke psychological license.
American Journal Of Pathology 05/2000; 156(4):1109-15. DOI:10.1016/S0002-9440(10)64979-6 · 4.60 Impact Factor