Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?
ABSTRACT Indole-3-carbinol (I3C) is one of several compounds in brassica vegetables that demonstrate anticarcinogenic effects in experimental animals. A review of Medline and CancerLit databases indicated that interest in I3C, as a cancer chemopreventive agent, has increased significantly in the past 5-10 years. Whereas most studies report inhibitory or protective effects of I3C in vivo, a few provide clear evidence for promotion or enhancement of carcinogenesis, depending upon the initiator, exposure protocol and species. In the absence of detailed information on the inhibitory and in particular, promotional mechanisms, it would seem advisable to proceed with caution before including I3C in extensive human clinical trials.
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ABSTRACT: Molecularly imprinting polymer technology is used to prepare a molecularly imprinted polymer (MIP) for the selective recognition of indole-3-carbinol (I3C), a chemopreventive and chemotherapeutic phytochemical associated with the anticancer activities of cruciferous vegetables. Prepolymerization study via nuclear magnetic resonance technique is done to choose the best functional monomer that establishes more interaction with the template. The prepared MIP is tested before in batch experiments and subsequently used as solid-phase extraction sorbent for the selective detection of I3C from standard solutions. In order to verify the selectivity of the MIP, the binding of structurally related compounds, such as indole-3-acetonitrile, teophylline, and tryptophan, on the polymer is investigated. The experiments indicate that the MIP is highly selective for I3C with an association constant of Ka = (1.37 ± 0.07) × 103M−1. Standard mixture solution loaded on MIP-SPE cartridge give a recovery of 95% for I3C, while the other compounds are totally eluted during washing step. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40819.Journal of Applied Polymer Science 10/2014; 131(19). DOI:10.1002/app.40819 · 1.40 Impact Factor
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ABSTRACT: The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site) signaling pathways have been conserved throughout evolution. Appropriately regulated signaling through each pathway is necessary for normal development and health, while dysregulation can lead to developmental defects and disease. Though both pathways have been vigorously studied, there is relatively little research exploring the possibility of crosstalk between these pathways. In this review, we provide a brief background on (1) the roles of both AHR and Wnt signaling in development and disease, and (2) the molecular mechanisms that characterize activation of each pathway. We also discuss the need for careful and complete experimental evaluation of each pathway and describe existing research that explores the intersection of AHR and Wnt signaling. Lastly, to illustrate in detail the intersection of AHR and Wnt signaling, we summarize our recent findings which show that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced disruption of Wnt signaling impairs fetal prostate development.International Journal of Molecular Sciences 10/2014; 15(10):17852-17885. DOI:10.3390/ijms151017852 · 2.34 Impact Factor
Article: Is It Safe to Eat Soy?[Show abstract] [Hide abstract]
ABSTRACT: No doubt you've heard lots of good things about soyfoods. According to a health claim sanctioned by the FDA, they can help to fight heart disease. 1 They may also make your bones stronger. 2, 3 And the biggest news about soyfoods over the past decade has been that they contain cancer-fighting compounds. 4 But just as it seemed that things couldn't get any better for soy, articles began to pop up on the internet saying that the pro-soy stories are nothing more than hype--and that the real scoop on soy is not nearly as positive. In fact, the stories say, eating soy could endanger your health. These claims against soy include allegations that it raises cancer risk, and causes nutrient deficiencies, osteoporosis, thyroid problems, reproductive difficulties, and Alzheimer's Disease. Making your way through the controversy can be confusing, especially since some of what the soy naysayers claim is based on some scientific data--although this doesn't mean that their conclusions are right. And it's true that some soy proponents may overstate the benefits of soy. Hopefully, we can tread a more even path here and convince you that, while soyfoods may not be the answer to all your problems, and while there certainly are a few unanswered questions, you can include soyfoods in a balanced and healthful vegan diet.