Childhood Diabetes in China: Enormous variation by place and ethnic group

University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Diabetes Care (Impact Factor: 8.42). 04/1998; 21(4):525-9. DOI: 10.2337/diacare.21.4.525
Source: PubMed

ABSTRACT To investigate the incidence rate of IDDM in China.
The Chinese IDDM registry was established in 1991 as part of the World Health Organization's Multinational Project for Childhood Diabetes (DiaMond) project. Twenty-two centers were developed to monitor the incidence of IDDM in children < 15 years of age. The population under investigation includes > 20 million individuals, representing approximately 7% of the children in China. Capture-recapture methods were used to estimate the ascertainment.
The overall ascertainment-corrected IDDM incidence rate in China was 0.51 per 100,000, the lowest rate ever reported. There was a 12-fold geographic variation (0.13-1.61 per 100,000). In general, the incidence rate was higher in the north and the east. There was a sixfold difference among ethnic groups (highest: Mongol group, 1.82 per 100,000; lowest: Zhuang group, 0.32 per 100,000).
China has an extremely low overall IDDM incidence rate. China also has the greatest geographic and ethnic variation seen for any country.

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Available from: Ze Yang, Jul 28, 2014
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    • "It has been hypothesized that ethnic differences may result in varying susceptibility to diseases. For example, the risk of type 2 diabetes is 13.5 times greater in Asian children than in White children (Drake et al., 2002), while the incidence of type 1 diabetes is about 30 times higher in Finland than in China (LaPorte et al., 1985; Yang et al., 1998). Asthma is one of the most common atopic diseases in developed countries; however, the rates of asthma and allergy are relatively lower in Chinese children (Warner, 1999; Williams et al., 1999; Beasley, 1998). "
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    Twin Research and Human Genetics 11/2012; 16(1):1-7. DOI:10.1017/thg.2012.113 · 2.30 Impact Factor
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    • "Of the 7 (13%) best scoring studies (good) (Razzak & Luby 1998; Kruse et al. 2003; Tercero & Anderson 2004; Van et al. 2006; Chiang et al. 2007; Zavareh et al. 2008; Azevedo-Silva et al. 2009), six were performed on hidden populations, injuries and mortality (30%), all in lowincome or lower-middle-income countries, and only one recent study assessed childhood acute leukaemia in Brazil (4%). The 13 (25%) intermediate (partly) scoring studies (Xia et al. 1995; Diallo et al. 1996; Ramachandran et al. 1996; Tull et al. 1998; Yang et al. 1998; Simondon & Khodja 1999; Chen et al. 2004; Khan et al. 2004; Platt et al. 2004; Luan et al. 2005; Mingoti et al. 2006; Cristiano et al. 2009; Odega et al. 2010) were proportionally equally divided over the three categories (around 25%). The proportions of best or intermediate scoring studies in the three categories were 58%, 28% and 25%, respectively. "
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    Tropical Medicine & International Health 05/2011; 16(8):1019-41. DOI:10.1111/j.1365-3156.2011.02790.x · 2.33 Impact Factor
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    • "Similar to other countries, our study shows marked variation in incidence of type 1 diabetes as the region specific incidence rates of type 1 were quite different. However, unlike some of the international studies conducted in Austria, China, or Germany, we did not observe a clear North-South gradient, based on comparison of regional incidence rates (Waldhor et al., 2000; Yang et al., 1998; Rosenbauer et al., 1999). "
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