Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data. Am J Psychiatry

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
American Journal of Psychiatry (Impact Factor: 12.3). 07/1998; 155(6):829-31.
Source: PubMed


The authors performed an analysis of their published chromosome 18 linkage data on 28 families in which there was bipolar disorder to test the potential of comorbid panic disorder to define a genetic subtype of bipolar disorder.
Families ascertained through probands with bipolar I disorder were stratified into three groups based on a history of panic disorder, panic attacks, or no panic attacks in the probands. Multipoint nonparametric linkage analysis was performed on data from bipolar I and II family members in each group.
Linkage scores for five consecutive 18q marker loci were highest in the families of the probands with panic disorder and lowest for the families of the probands without panic attacks.
This study supports the authors' previously reported clinical hypothesis of a genetic subtype of bipolar disorder identified by comorbid panic disorder. The hypothesis merits prospective testing.

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    • "Subtypes may be characterized by clinical variables, including patterns of co-morbid psychiatric symptoms and disorders (Nurnberger, 2002; Cassidy et al. 2008; Cassano et al. 2009). The creation of homogeneous BPI subgroups based on co-morbid conditions has modestly improved the success of genetic mapping (MacKinnon et al. 1998; Nurnberger, 2002; Schulze & McMahon, 2003; MacQueen et al. 2005; Payne et al. 2005; Cheng et al. 2006; Saunders et al. 2009). For example, three subtypes of BPI, as defined by co-morbidity, have provided some of the strongest evidence of linkage to genomic regions: co-morbid panic disorder, co-morbid psychotic symptoms, and pure BPI with low rates of co-morbidity (MacQueen et al. 2005). "
    Psychological Medicine 07/2015; 45:2181-2196. · 5.94 Impact Factor
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    • "In addition, the clinical heterogeneity of BP may be related to genetic heterogeneity. Studies hypothesize a relative genetic factor between BP and AD [31]. Since AD is the most prevalent comorbidity, past inconsistent genetic findings in BP may be related to the exclusion of AD comorbidity or not. "
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    • "Many previous studies have reported that PD the most frequent comorbid AnxD in bipolar subjects (Chen & Dilsaver, 1995a; Kessler, 1999; McElroy et al., 2001). The link between BPD and PD has been demonstrated by genetic studies (Doughty, Wells, Joyce, Olds, & Walsh, 2004; MacKinnon et al., 1998). Even in the Epidemiological Catchment Area (ECA) study, lifetime prevalence of PD was 21.0% in those with BPD-I (Chen & Dilsaver, 1995a). "
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