Long-term intellectual and behavioral outcomes of children with febrile convulsions.
ABSTRACT Hospital-based studies have reported that children with febrile convulsions have subsequent mental retardation and behavior problems. In contrast, population-based studies have reported a better outcome.
We identified 398 children with febrile convulsions among 14,676 children enrolled in the Child Health and Education Study, a national population-based study in the United Kingdom of children born in one week in April 1970. The children were comprehensively assessed at the age of 10. After excluding 16 children who had neurodevelopmental problems before their first febrile convulsion and 1 child whose case was atypical, we studied 381 children, 287 with simple febrile convulsions and 94 with complex febrile convulsions. We compared them with the rest of the cohort using measures of academic progress, intelligence, and behavior that included questionnaires, standardized tests, and formal tests.
At the 10-year assessment, only 4 of 102 measures of academic progress, intelligence, and behavior differed significantly between the entire group of children with febrile convulsions and the group without febrile convulsions -- no more than would be expected by chance. Similar results were found when children with simple febrile convulsions and those with complex febrile convulsions were analyzed separately. The children with recurrent episodes of febrile convulsions had outcomes similar to those of the children with only one episode each. Special schooling was required for more children who had febrile convulsions in the first year of life than for those who had had them later in life (5 of 67, or 7.5 percent, vs. 4 of 265, or 1.5 percent; P=0.02), but these numbers were small.
Children who had febrile convulsions performed as well as other children in terms of their academic progress, intellect, and behavior at 10 years of age.
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ABSTRACT: E pilepsy in young children should always be considered as a symptom of an underlying brain disease, and therefore needs diagnostic screening, including neuro-genetic, neurometabolic, and neuroradiologic testing. Seizures are common in infancy and reflect a variety of underlying causes. The most frequent seizure in that age group is febrile seizure, which is usually benign and has no risk on the further child's development. 1-3 On the other hand, infantile spasm in infancy indicates an age-specific catastrophic epilepsy syndrome, with major negative implications for the development of the child. 4,5 The two most important questions regarding seizures usually asked by parents and caregivers are whether the seizures can be controlled and whether the epilepsy will affect the child development. We performed a retrospective study to find out risk factors for outcomes in infants with epilepsy. Abstract Background Epilepsy in young children should always be considered as a symptom of an underlying brain disease. Parents and caregivers often asked whether the seizures can be controlled and whether the epilepsy will affect the child development. Objective To find out risk factors influencing the outcomes in infants with epilepsy. Methods This was a retrospective study on infants aged 1 month until 12 months with recurrent epileptic seizures. We looked for the risk factors as sex, types of medication, age at onset of seizure, epilepsy syndrome, etiology of epilepsy, history of neonatal seizure, first EEG features, and type of seizure for the last 6 month-period. The outcomes evaluated were controlled seizure and developmental status. Results Hundred forty infants with epilepsy were reviewed, consisted of 84 (60%) infants with symptomatic epilepsy, and 56 (40%) infants categorized as idiopathic. Forty-six (33%) infants had controlled seizure, while 94 (67%) infants had uncontrolled seizure. Abnormal developmental status was found in 75 infants (54%). Abnormal developmental status was more found in infants with polytherapy, age at onset of 1-4 months, symptomatic epilepsy, positive remote symptomatic, history of neonatal seizure, abnormality of first EEG, and uncontrolled seizure. Uncontrolled seizure of epilepsy was more found in infants with polytherapy, early age at onset (1-4 month old), symptomatic epilepsy, positive remote symptomatic, history of neonatal seizure, and abnormality of first EEG. Conclusion Our data indicate that classifying syndrome of epilepsy through diagnostic screening and age of onset are important to determine the outcomes. [Paediatr Indones 2007;47:202-206].
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ABSTRACT: Objective. The study aimed to evaluate the influences of coadministration of antiepileptic drugs (AEDs) on an antimalarial candidate 99/411 pharmacokinetic (PK) profile. Method. For this, single oral dose PK drug interaction studies were conducted between 99/411 and FDA approved AEDs, namely, Phenytoin (PHT), Carbamazepine (CBZ), and Gabapentin (GB) in both male and female SD rats, to assess the coadministered and intersexual influences on 99/411 PK profile. Results. Studies revealed that there were no significant alterations in the PK profile of 99/411 upon PHT and CBZ coadministration in both male and female rats, while systemic exposure of 99/411 was significantly increased by about 80% in female rats upon GB coadministration. In terms of AUC, there was an increase from 2471 ± 586 to 4560 ± 1396 ng·h/mL. Overall, it was concluded that simultaneous administration of AEDs with 99/411 excludes the requirements for dose adjustment, additional therapeutic monitoring, contraindication to concomitant use, and/or other measures to mitigate risk, except for GB coadministration in females. These findings are further helpful to predict such interactions in humans, when potentially applied through proper allometric scaling to extrapolate the data.Malaria research and treatment. 01/2014; 2014:756965.
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ABSTRACT: It was previously demonstrated that MMRV vaccine causes a higher rate of febrile convulsions (FC) compared to the MMR vaccine. Additional risk factors for FC include age, familial tendency, day care attendance, viral diseases, complications at birth and developmental delay.Vaccine 07/2014; · 3.49 Impact Factor