Spiny Keratoderma: A Common Under-Reported Dermatosis

Wayne State University, Detroit, Michigan, USA.
The Journal of Dermatology (Impact Factor: 2.25). 07/1998; 25(6):353-61. DOI: 10.1111/j.1346-8138.1998.tb02414.x
Source: PubMed


Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles, with a distinct histology characteristic of a parakeratotic column above a hypogranular epidermis. We report six cases discovered within a year and review the present literature on spiny keratoderma. The average age of the patients was 57 years. Fifty-seven percent of the patients were male and forty-three percent were female. The duration of lesions ranged from 4 months to 40 years. Symptoms were variable, however, lesions were often unnoticed by the patient. The location of the lesions involved the palms and soles or the palms alone. Past medical history was significant for hypertension and hyperlipidemia treated with HMG-CoA reductase inhibitors. Lesions often occurred in patients involved in manual labor. Spiny keratoderma is a relatively common under-reported dermatosis found most often in older patients with history of manual labor and is possibly related to treatment with HMG-CoA reductase inhibitors.

12 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: Multiple minute digitate hyperkeratoses (MMDH) is a relatively rarely described disorder of keratinization of unknown origin. We noticed that MMDH has been reported in the literature under a variety of synonyms. We observed two patients with MMDH and reviewed the literature. We concluded that MMDH is a skin disorder which can be properly separated from other disorders of keratinization and classified as a distinct entity. Two forms of MMDH exist: MMDH of early onset and MMDH of late onset. Both forms are described occurring in a widespread and in a localized pattern. The early onset form may be hereditary, the late onset form may present as part of a paraneoplastic syndrome.
    European journal of dermatology: EJD 10/1999; 9(6):460-5. · 1.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report two patients with spiny keratoderma of the palms and soles characterized by multiple tiny keratotic plugs on the palms and soles. This disease was reported to be possibly associated with internal malignancies. We found a tumor from the esophagus to cardia in one patient. Another had no tumor but the lesion occurred soon after a severe bronchial asthma attack. Causal relation between spiny keratoderma of the palms and soles and bronchial asthma is obscure. Since this disease has been under-diagnosed and under-reported, it is important for dermatologists to keep spiny keratoderma of the palms and soles in mind in daily clinical examinations.
    European journal of dermatology: EJD 11/1999; 10(7):542-5. · 1.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Spiny keratoderma is a descriptive term used to encompass a variety of unusual, disparate keratodermas. Spiny keratoderma has been associated with lipid abnormalities and has been limited to the palms and soles in some individuals. We describe an acquired case of spiny keratoderma in which an adult woman developed filiform lesions predominating on the trunk and proximal extremities. Treatment with topical emollients and keratolytic agents was unsuccessful, but topical tazarotene led to long periods of resolution. She has had no other associated abnormalities. The clinical features and differential diagnosis of spiny keratoderma are reviewed.
    Cutis; cutaneous medicine for the practitioner 10/2000; 66(3):191-2. · 0.72 Impact Factor
Show more